HSD3B7 Antibodies

AND HSD3B7 ELISA kits, HSD3B7 Proteins

Many biological assays use antibodies to detect HSD3B7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HSD3B7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HSD3B7 antibodies...

We validate the specificity of these antibodies to HSD3B7 by testing them on tissues known to express HSD3B7 positively and negatively. Browse below to find the HSD3B7 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HSD3B7 Infographic by Boster Bio

All HSD3B7 Products

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Product

Figures

Specificity

Applications

Price

Anti-beta-HSD7 HSD3B7 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A10025
100ul

HSD3B7 (NM_025193) Human Over-expression Lysate

Human

$628
Cat # LS080270
100 µg

Anti-HSD3B7 Antibody Picoband®

Human

ELISA, IF, ICC, WB

$370
Cat # A10025-1
100 µg/vial

HSD3B7 Overview

Facts about 3 beta-hydroxysteroid dehydrogenase type 7.

HSD3B7 3D structure. Source: alphafold

3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7)

The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols.

Doesn't metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870).

Gene Information

Human
Gene Name:	HSD3B7
Uniprot:	Q9H2F3
Entrez:	80270

Family

Belongs to:

3-beta-HSD family

Alternative Names

3 beta-hydroxy-delta 5-C27-steroid oxidoreductase; 3 beta-hydroxysteroid dehydrogenase type 7; 3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-HSD VII; 7-alpha-diol 3-beta-dehydrogenase; C(27) 3-beta-HSD; C(27)-3BETA-HSD; Cholest-5-ene-3-beta; EC 1.1.1.-; EC 1.1.1.181; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7,3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase; PFIC4; SDR11E3; short chain dehydrogenase/reductase family 11E, member 3

Molecular Weight

Mass (kDA):
41.016 kDA

Genomic Context


Human

Location:	16p11.2
Sequence:	16; NC_000016.10 (30985189..30989152)

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Liver Diseases
Cholestasis
Neonatal Cholestasis
Icterus
Liver Dysfunction
Malabsorption Syndrome
Cholangiocarcinoma
Jaundice, Obstructive
Glioblastoma Multiforme
Intrahepatic Cholestasis
Inborn Errors Of Metabolism
Glioblastoma

Rickets
Metabolic Diseases
Neoplasms
Deficiency Diseases
Liver Cirrhosis
Alzheimer's Disease

Interacting Proteins

KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-2
NOTCH2NL

SPRY2

Pathways

Translation
Transport
Cell Cycle
Steroid Biosynthetic Process
Metaphase
Oocyte Maturation

Biosynthetic Process

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HSD3B7

References

PMID: 11067870 by Schwarz M., et al. The bile acid synthetic gene 3beta-hydroxy-delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis.

PMID: 12679481 by Cheng J.B., et al. Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease.