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- Table of Contents
Facts about Inactive heparanase-2.
.
Human | |
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Gene Name: | HPSE2 |
Uniprot: | Q8WWQ2 |
Entrez: | 60495 |
Belongs to: |
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glycosyl hydrolase 79 family |
heparanase 2
Mass (kDA):
66.596 kDA
Human | |
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Location: | 10q24.2 |
Sequence: | 10; NC_000010.11 (98457077..99235875, complement) |
Widely expressed, with the highest expression in brain, mammary gland, prostate, small intestine, testis and uterus. In the central nervous system, expressed in the spinal chord, caudate nucleus, thalamus, substantia nigra, medulla oblongata, putamen and pons. In the urinary bladder, expressed in longitudinal and circular layers of detrusor muscle. Found both in normal and cancer tissues.
Secreted, extracellular space, extracellular matrix.
PMID: 11027606 by McKenzie E., et al. Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member.
PMID: 20560209 by Pang J., et al. Loss-of-function mutations in HPSE2 cause the autosomal recessive urofacial syndrome.