Homer protein homolog 3 Antibodies

Homer protein homolog 3 (HOMER3)

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic areas of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3.

By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and might play an important role in maintaining the plasticity at glutamatergic synapses.

Gene Information

Human
Gene Name:	HOMER3
Uniprot:	Q9NSC5
Entrez:	9454

Family

Belongs to:
Homer family

Alternative Names

homer homolog 3 (Drosophila); homer protein homolog 3; Homer, neuronal immediate early gene, 3; HOMER-3; VESL3

Molecular Weight

Mass (kDA):
39.836 kDA

Genomic Context

Human
Location:	19p13.11
Sequence:	19; NC_000019.10 (18929201..18941258, complement)

Subcellular Localizations

Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Postsynaptic density of neuronal cells.

Diseases

• Urinary Incontinence
• Leukemogenesis
• Anxiety Disorders
• Childhood Acute Myeloid Leukemia
• Hematopoietic Neoplasms
• Leukemia, Myelocytic, Acute
• Patient Dependence On
• Malignant Neoplasms
• Myeloid Leukemia

• Leukemia
• Alzheimer's Disease
• Senile Plaques
• Stress, Psychological

Interacting Proteins

• ABI2
• ABI3
• DYNLL2
• EAF1
• EFHC1

• EIF3D
• FAT1
• HOMER1
• LNX1
• MOS

• NEBL
• PAX6
• PKN1
• POM121
• PPP1R18

• PRCC
• PSMA1
• SNRPF
• USP2
• WIPF1

Pathways

• Cell Activation
• Membrane Depolarization
• Mrna Transcription
• Regulation Of T Cell Activation
• T Cell Activation
• Localization

• Secretion

PTMs

• Phosphorylation

• Dephosphorylation

Research Areas

• Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HOMER3

Boster Bio - Best Uses Of The HOMER3 Marker

This article will explain the reasons Boster Bio uses DPH3 homolog antibody in its tests. It will also provide the background of Steven Boster, who developed these antibodies. Additionally, you'll learn about the molecular basis behind Homer3. This marker is essential for the development of mouse embryos and , consequently, many of the assays that employ Homer3 as targets are also useful for understanding the development stage of a specific species.

The history of Steven Boster

If you're interested in Steve's background, the internet is the best way to research. You can search for a wide range of public records on Steve Boster including his past and current addresses, mobile phone numbers, email addresses and known relatives. You can also filter Steve Boster's public information by state to find specific details. Here's a deeper look into his personal life. Here are a few things you should be aware of about Steve Boster.

Steve Boster died on June 6, 2022. He was born in Joliet (IL) and was the son and daughter of Donald, Sr., and Evelyn Meier Boster. He was a veteran of the U.S. Army, and was a member of Concordia Hall in Staunton. Among his survivors are 2 daughters Natosha and Crystal Boster, 6 grandchildren four brothers who were Jack Boster and Sandra Blanton, daughter-inlaw Lisa Milton, and sister-in-law David, Jr.

Biology of the molecular

The HOMER3 gene is an cellular protein found in the PSD of neurons. It interacts with type I metabotropic Glutamate receptors and triggers IP3's Ca2+ release. Homer3 belongs to the HOMER protein family, which is involved in receptor trafficking and post-synaptic signalling. HOMERs play a significant function in brain development in addition to their role in neurotransmission.

A screening of human brain transcripts revealed that PAX6 is co-expressed with, HOMER3, and DNCL1. The C-terminal protein did not interact with Homer3 while the PST domain screen yielded 62 colonies positive. The sequences of the resulting DNAs confirmed that HOMER3 was expressed by two of the interacting genes PAX6PST (TRIM11), according to sequences. These plasmids also co-expressed DNCL1, TriM11, and PAX6.

Antibodies against Homer3 showed that the protein was co-located with RyR1. Antipan Homer3 antibodies also interact with the mGluR1 receptor. Homer is also known to affect the rate of degradation of the transmitter receptor mGluR1 in the brain. It is implicated in the formation of cerebellitis. It is characterized by the presence of anti-Homer3 antibodies in the blood serum.

There are many possibilities for using the HOMER3 gene. One of them is in the conversion of neuronal signals into mechanical signals. It isn't clear what the specific function of this gene plays in the cell biology. Its mutations could lead to the inactivation or deletion of the gene. Some of them are functionally insignificant. In the long term, this gene is expected to be significant in a variety of important fields.

Homer1 is often associated with schizophrenia and other mental illnesses. However its role in spinal cord morphogenesis is not fully understood. The Homer1 gene regulates glutamatergic synapses as well as spine morphogenesis. In-silico screening for Homer1 interfacing protein has revealed a new way to ensure the stability of the spine. The findings have implications for neuropsychiatric diseases like autism and bipolar disorder.

Homer1a has been associated with the reduction of depressive-like behavior mice following the administration of imipramine or ketamine. The results of these studies show that the study of the HOMER3 pattern can provide insights into strategies for treating patients. Homer1b/c also colocalizes in the dendritic shaft as well as the spine heads with ankyrin G. The latter is linked to larger spine heads.