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- Table of Contents
Facts about Homer protein homolog 2.
May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be otherwise regulated and might play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459).
Human | |
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Gene Name: | HOMER2 |
Uniprot: | Q9NSB8 |
Entrez: | 9455 |
Belongs to: |
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Homer family |
ACPD; CPD; cupidin; homer homolog 2 (Drosophila); homer homolog 3; homer protein homolog 2; homer, neuronal immediate early gene, 2; HOMER-2; HOMER2A; HOMER-2A; HOMER2B; HOMER-2B; Vesl-2
Mass (kDA):
40.627 kDA
Human | |
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Location: | 15q25.2 |
Sequence: | 15; NC_000015.10 (82836946..82986176, complement) |
Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, stereocilium. Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
PMID: 9808458 by Xiao B., et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.
PMID: 10653696 by Soloviev M., et al. Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing.