Homer protein homolog 2 Antibodies

AND HOMER2 ELISA kits, Homer protein homolog 2 Proteins

Many biological assays use antibodies to detect Homer protein homolog 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Homer protein homolog 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Homer protein homolog 2 antibodies...

We validate the specificity of these antibodies to Homer protein homolog 2 by testing them on tissues known to express HOMER2 positively and negatively. Browse below to find the HOMER2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HOMER2 Infographic by Boster Bio

All HOMER2 Products

Product

Figures

Specificity

Applications

Price

HOMER2 (NM_004839) Human Recombinant Protein

$1249
Cat # PROTQ9NSB8
20 µg

Anti-HOMER2 Mouse Monoclonal Antibody [Clone ID: OTI1D1]

Human, Mouse, Rat

$523
Cat # M06474
100 µl

HOMER2 (NM_004839) Human Over-expression Lysate

Human

$628
Cat # LS009455
100 µg

HOMER2 Overview

Facts about Homer protein homolog 2.

HOMER2 3D structure. Source: alphafold

Homer protein homolog 2 (HOMER2)

Binds and cross-links cytoplasmic areas of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it helps the coupling of surface receptors to intracellular calcium release.

May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be otherwise regulated and might play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459).

Gene Information

Human
Gene Name:	HOMER2
Uniprot:	Q9NSB8
Entrez:	9455

Family

Belongs to:

Homer family

Alternative Names

ACPD; CPD; cupidin; homer homolog 2 (Drosophila); homer homolog 3; homer protein homolog 2; homer, neuronal immediate early gene, 2; HOMER-2; HOMER2A; HOMER-2A; HOMER2B; HOMER-2B; Vesl-2

Molecular Weight

Mass (kDA):
40.627 kDA

Genomic Context


Human

Location:	15q25.2
Sequence:	15; NC_000015.10 (82836946..82986176, complement)

Subcellular Localizations

Cytoplasm. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, stereocilium. Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.

Diseases

Malignant Neoplasms
Congenital Diaphragmatic Hernia
Congenital Abnormality
Protrusion
Hernia
Diaphragmatic Hernia
Urinary Incontinence
Adenoma
Non-neoplastic Disorder
Substance-related Disorders
Aneuploidy

Unbalanced Translocation
Patient Dependence On
Neoplasms
Nervousness
Globus Hystericus
Hyperlipidemia

Interacting Proteins

LZTS2
RNF41

Pathways

Sensitization
Localization
Cell Adhesion
Diaphragm Development
Cell Activation
Translational Initiation
Dna Hypermethylation
T Cell Activation
Dendritic Spine Development
Neurogenesis
Methylation
Tissue Development

Membrane Depolarization
System Development
Translation
Axon Guidance
Locomotion
Regulation Of T Cell Activation
Secretion

PTMs

Methylation

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HOMER2

References

PMID: 9808458 by Xiao B., et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.

PMID: 10653696 by Soloviev M., et al. Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing.