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- Table of Contents
Facts about Biotin--protein ligase.
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Human | |
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Gene Name: | HLCS |
Uniprot: | P50747 |
Entrez: | 3141 |
Belongs to: |
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biotin--protein ligase family |
Biotin apo-protein ligase; biotin--protein ligase; EC 6.3.4.-; HCSholocarboxylase synthetase, EC 6.3.410holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase(ATP-hydrolysing)) ligase); holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase(ATP-hydrolysing)) ligase); holocarboxylase synthetase (biotin-[proprionyl-Coenzyme A-carboxylase(ATP-hydrolysing)] ligase)
Mass (kDA):
80.76 kDA
Human | |
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Location: | 21q22.13 |
Sequence: | 21; NC_000021.9 (36748625..36990255, complement) |
Mostly expressed in muscle, placenta, in lesser extent in the brain, kidney, pancreas, liver and lung.
Cytoplasm. Mitochondrion.
PMID: 7842009 by Suzuki Y., et al. Isolation and characterization of mutations in the human holocarboxylase synthetase cDNA.
PMID: 9037601 by Ohira M., et al. Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21.