HECW2 Antibodies

AND HECW2 ELISA kits, HECW2 Proteins

Many biological assays use antibodies to detect HECW2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HECW2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HECW2 antibodies...

We validate the specificity of these antibodies to HECW2 by testing them on tissues known to express HECW2 positively and negatively. Browse below to find the HECW2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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HECW2 Infographic by Boster Bio

All HECW2 Products

Product

Figures

Specificity

Applications

Price

Anti-NEDL2 HECW2 Antibody (Internal)

Human

ELISA, WB

$380
Cat # A08779
100ul

NEDL2 (HECW2) (NM_020760) Human Recombinant Protein

$1249
Cat # PROTQ9P2P5
20 µg

NEDL2 (HECW2) (NM_020760) Human Over-expression Lysate

Human

$960
Cat # LS057520
100 µg

HECW2 Overview

Facts about E3 ubiquitin-protein ligase HECW2.

HECW2 3D structure. Source: alphafold

E3 ubiquitin-protein ligase HECW2 (HECW2)

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487).

Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). .

Gene Information

Human
Gene Name:	HECW2
Uniprot:	Q9P2P5
Entrez:	57520

Family

Belongs to:

No superfamily

Alternative Names

C2 and WW domain-containing protein 2; DKFZp686M17164; EC 6.3.2; EC 6.3.2.-; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; NEDD4-like E3 ubiquitin-protein ligase 2

Molecular Weight

Mass (kDA):
175.769 kDA

Genomic Context


Human

Location:	2q32.3
Sequence:	2; NC_000002.12 (196194072..196593692, complement)

Tissue Specificity

Predominantly expressed in adult brain, lung and heart.

Subcellular Localizations

Cytoplasm. Cytoplasm, cytoskeleton, spindle.

Diseases

Edema
Malignant Neoplasms
Male Infertility
Alzheimer's Disease
Infertility

Pathways

Aging
Localization
Nuclear Export
Autophagy

PTMs

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HECW2

References

PMID: 12890487 by Miyazaki K., et al. A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity.

PMID: 24163370 by Lu L., et al. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase- promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.