SRGAP1 Antibodies

AND SRGAP1 ELISA kits, SRGAP1 Proteins

Many biological assays use antibodies to detect SRGAP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SRGAP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SRGAP1 antibodies...

We validate the specificity of these antibodies to SRGAP1 by testing them on tissues known to express SRGAP1 positively and negatively. Browse below to find the SRGAP1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SRGAP1 Infographic by Boster Bio

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SRGAP1 (NM_020762) Human Over-expression Lysate

Human

$628
Cat # LS057522
100 µg

SRGAP1 Overview

Facts about SLIT-ROBO Rho GTPase-activating protein 1.

SRGAP1 3D structure. Source: alphafold

SLIT-ROBO Rho GTPase-activating protein 1 (SRGAP1)

GTPase-activating protein for RhoA and Cdc42 small GTPases.
Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration.

SLIT2, probably through interaction with ROBO1, raises the interaction of SRGAP1 with ROBO1 and inactivates CDC42. .

Gene Information

Human
Gene Name:	SRGAP1
Uniprot:	Q7Z6B7
Entrez:	57522

Family

Belongs to:

No superfamily

Alternative Names

ARHGAP13srGAP1; FLJ22166; KIAA1304SLIT-ROBO Rho GTPase-activating protein 1; Rho GTPase-activating protein 13; SLIT-ROBO Rho GTPase activating protein 1

Molecular Weight

Mass (kDA):
124.264 kDA

Genomic Context


Human

Location:	12q14.2
Sequence:	12; NC_000012.12 (63843911..64162217)

Tissue Specificity

Expressed in brain, lung, kidney, and testis.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Malignant Neoplasm Of Lung
Carcinogenesis
Chondrosarcoma
Nervousness
Brain Neoplasms
Salivary Gland Neoplasms
Disease Of Adrenal Medulla
Malignant Neoplasm Of Kidney
Peripheral Nerve Injuries

Melanoma
Sciatic Neuropathy
Head And Neck Neoplasms
Malignant Neoplasm Of Pancreas
Chronic Lymphocytic Leukemia
Neck Neoplasm
Hematologic Neoplasms

Interacting Proteins

ARHGEF7
HTT
YWHAZ

Pathways

Axon Guidance
Localization
Cell Migration
Cell Proliferation
Mitosis
Neutrophil Chemotaxis
Brain Development
Neurogenesis
Larval Development
Cytokinesis
Leukocyte Migration
Eosinophil Chemotaxis

Regeneration
Sensitization
Chemotaxis
Cell Motility
Cell Cycle
Cell Morphogenesis
Protein Ubiquitination

PTMs

Acetylation

Ubiquitination

Research Areas

Growth and Development
Neuronal Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SRGAP1

References

PMID: 11672528 by Wong K., et al. Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.

PMID: 22467852 by Coutinho-Budd J., et al. The F-BAR domains from srGAP1, srGAP2, and srGAP3 differentially regulate membrane deformation.