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, No Gclids
Galactocerebrosidase Antibodies
AND GALC ELISA kits, Galactocerebrosidase Proteins
Many biological assays use antibodies to detect Galactocerebrosidase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Galactocerebrosidase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Galactocerebrosidase antibodies...
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GALC Infographic by Boster Bio
All GALC Products
Product
Figures
Specificity
Applications
Price
Human
$628
Cat # LS002581
100 µg
Cat # LS002581
100 µg
GALC Overview
Facts about Galactocerebrosidase.
Galactocerebrosidase (GALC)
Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a significant lipid in myelin, kidney and epithelial cells of small intestine and colon.
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Gene Information
| Human | |
|---|---|
| Gene Name: | GALC |
| Uniprot: | P54803 |
| Entrez: | 2581 |
Family
| Belongs to: |
|---|
| glycosyl hydrolase 59 family |
Alternative Names
EC 3.2.1.46; Galactocerebrosidase; Galactocerebroside beta-galactosidase; galactosylceramidase (Krabbe disease); Galactosylceramidase; Galactosylceramide beta-galactosidase; Galactosylceraminidase; GALC; GALCERase
Molecular Weight
Mass (kDA):
77.063 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q31.3 |
| Sequence: | 14; NC_000014.9 (87933014..87993665, complement) |
Tissue Specificity
Detected in urine. Detected in testis, brain and placenta (at protein level). Detected in kidney and liver.
Subcellular Localizations
Lysosome.
Diseases
- Globoid Cell Leukodystrophy
- Leukodystrophy
- Nervousness
- Demyelination
- Lysosomal Storage Diseases
- Neurodegenerative Disorders
- Nerve Degeneration
- Demyelinating Diseases
- Infantile Globoid Cell Leukodystrophy
- Storage Disease
- Gliosis
Pathways
- Myelination
- Localization
- Cell Death
- Pathogenesis
- Transport
- Programmed Cell Death
- Glycosylation
- Secretion
- Intracellular Transport
- Secretory Pathway
- Neurogenesis
- Endocytosis
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GALC
bosterbio.com/bosterbio-gene-info-cards/GALC
References
PMID: 7601472 by Luzi P., et al. Structure and organization of the human galactocerebrosidase (GALC) gene.
PMID: 9434153 by Sakai N., et al. Human galactocerebrosidase gene: promoter analysis of the 5'-flanking region and structural organization.