Granzyme M Antibodies

Granzyme M (GZMM)

Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin.

Promotes caspase activation and subsequent apoptosis of target cells. .

Gene Information

Human
Gene Name:	GZMM
Uniprot:	P51124
Entrez:	3004

Family

Belongs to:
peptidase S1 family

Alternative Names

EC 3.4.21; EC 3.4.21.-; granzyme M (lymphocyte met-ase 1); granzyme M; Hu-Met-1; LMET1; lymphocyte met-ase 1; Met-1 serine protease; MET1met-ase; Met-ase; Natural killer cell granular protease

Molecular Weight

Mass (kDA):
27.545 kDA

Genomic Context

Human
Location:	19p13.3
Sequence:	19; NC_000019.10 (544053..549922)

Tissue Specificity

Highly and constitutively expressed in activated natural killer (NK) cells.

Subcellular Localizations

Secreted. Cytoplasmic granule. Granules of large granular lymphocytes.

Diseases

• Neoplasms
• Leukemia
• Neoplasms, Experimental
• Leukemia, T-cell
• Enteropathy-associated T-cell Lymphoma
• Carcinoma
• Septic Shock
• Edema
• Malignant Neoplasms
• Cytomegalovirus Infections
• Innate Immune Response
• Lymphoma
• Mycoses

• T-cell Lymphoma
• Mycosis Fungoides
• Malignant Squamous Cell Neoplasm
• Peripheral T-cell Lymphoma
• Ki-1+ Anaplastic Large Cell Lymphoma
• Angioimmunoblastic Lymphadenopathy
• Nose Neoplasms

Pathways

• Cell Death
• Cytolysis
• Proteolysis
• Transport
• Cell Development
• Glycosylation
• Dna Repair
• Localization
• Release Of Cytochrome C From Mitochondria
• Reverse Transcription
• Cytokine Production

• Cellular Localization
• Interphase
• Exocytosis
• Rna Interference
• Viral Replication

PTMs

• Cleavage
• Phosphorylation

• Glycosylation
• Myristoylation

Research Areas

• Adaptive Immunity
• Apoptosis
• Cancer
• Immunology
• Innate Immunity

• Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GZMM

Boster Bio Anti-Granzyme M GZMM Marker

If you're interested in using the Boster Bio Anti-Granzyme M GZMM Marker, then you've come to the right place. Here, you'll find information about the product's uses and specifications. This article will also address the Boster bio Anti-Granzymem GZMM antibody. Continue reading to find out more. Listed below are some of the best uses of this antibody.

Boster Bio Anti-Granzyme M GZMM Marker

The Boster Bio Anti-Granzyme-M/GZMM Marker is a research-grade antibody that reacts with the Mouse, Rat, and Human forms of the Granzyme M protein. This product reacts with the antigen at a 28KD molecular weight. It was tested in a WB application. Boster Bio Anti-Granzyme-M/GZMMMarker uses proprietary dyads to detect the proteins.

The gzm protein is a subset of neutral serine proteases expressed by human natural killer cells. These cells secrete immune effector molecules called granzymes into large cytoplasmic granules. There are three main forms: granzyme H and granzyme b.

Specifications

The term "active" can be somewhat ambiguous when it comes to determining the activity a GZMM marker. A GZMM active protein vial may become trapped inside a sealed vial during shipment. It may be necessary to briefly centrifuge this product with a tabletop centrifuge prior to shipping. Dry ice is required for some products. Additional fees may apply for these products.

Applications

There are many uses for the GZMM marker, but the most immediate is the potential to develop new cancer therapies. This gene is expressed in solid tumor cells and is thought to contribute to cancer progression. The GZMM Marker was found to be expressed in both mouse tumor cells and human cancer cells. It was also linked with the development lung cancer in mice. The survival rates of tumor-bearing mice were shorter than those of the controls. The median survival time for 4T1-GZMM-transfected animals was 31 days, while that of controls was 37 days.

The GZMM Marker is produced in a number of different ways. First, it's used to detect gene expression in samples. One example of this is where the mRNA for a sample can be isolated and hybridized with probes. The marker mRNA can be detected by the PCR extension-labelling method.

The GZMM Marker was discovered accidentally in microarray results. Researchers looked into its biological significance and discovered that GZMM cleaves Ezrin (a peptide complex containing a-tubulin proteins). In clinical samples, GZMM also inhibited cancer invasion and EMT. As a result, GZMM has been identified as a potential weapon of tumor cells. Further understanding of chemoresistance will be enhanced by the discovery and use of the GZMM Marker.

Recent research has shown that the GZMM Marker enhances chemoresistance of murine tumor cells. 5-FU treatment of CT26-NC cells enhanced GZMM expression. Western blots revealed that 5-FU treatment resulted a markedly elevated level of GZMM. These results suggest that GZMM may increase the cell's tolerance to common chemotherapeutics.

These findings support the concept that GZMM induces EMT. It is known to regulate STAT3 as a transcription factor, and to regulate various aspects of EMT and invasion. However, other models are yet to be revealed. Further research is required to clarify how GZMM Marker induces EMT. With these findings, future treatments may be developed to target cancer cells. The GZMM will continue to improve cancer patients' quality of life.