Gasdermin-C Antibodies

AND GSDMC ELISA kits, Gasdermin-C Proteins

Many biological assays use antibodies to detect Gasdermin-C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Gasdermin-C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Gasdermin-C antibodies...

We validate the specificity of these antibodies to Gasdermin-C by testing them on tissues known to express GSDMC positively and negatively. Browse below to find the GSDMC antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GSDMC Infographic by Boster Bio

All GSDMC Products

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Anti-GSDMC/Gasdermin C Antibody

4 Q&As

Human

$360
Cat # A13060
100 µl

GSDMC (NM_031415) Human Over-expression Lysate

Human

$960
Cat # LS056169
100 µg

GSDMC Overview

Facts about Gasdermin-C.

GSDMC 3D structure. Source: alphafold

Gasdermin-C (GSDMC)

The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores (PubMed:27281216).

The physiological relevance of this observation is unknown (Probable). .

Gene Information

Human
Gene Name:	GSDMC
Uniprot:	Q9BYG8
Entrez:	56169

Family

Belongs to:

gasdermin family

Alternative Names

gasdermin C; gasdermin-C; Melanoma-derived leucine zipper-containing extranuclear factor; MLZEmelanoma-derived leucine zipper, extra-nuclear factor

Molecular Weight

Mass (kDA):
57.692 kDA

Genomic Context


Human

Location:	8q24.21
Sequence:	8; NC_000008.11 (129705903..129786624, complement)

Tissue Specificity

Expressed mainly in trachea and spleen (PubMed:11223543). In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium (PubMed:19051310).

Subcellular Localizations

Cytoplasm, cytosol. Cell membrane.

Diseases

Malignant Paraganglionic Neoplasm
Neoplasms
Malignant Neoplasms
Neoplasm Metastasis
Melanoma
B16 Malignant Melanoma
Stomach Neoplasms
Malignant Squamous Cell Neoplasm
Metastatic Melanoma
Skin Neoplasms
Malignant Tumor Of Eye
Neoplasms, Experimental

Carcinogenesis
Carcinoma
Melanoma, Experimental
Malignant Neoplasm Of Stomach
Disorder Of Eye
Colorectal Cancer
Esophageal Neoplasms

Pathways

Pigmentation

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GSDMC

References

PMID: 11223543 by Watabe K., et al. Structure, expression and chromosome mapping of MLZE, a novel gene which is preferentially expressed in metastatic melanoma cells.

PMID: 17350798 by Tamura M., et al. Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.