GRB14 Antibodies

AND GRB14 ELISA kits, GRB14 Proteins

Many biological assays use antibodies to detect GRB14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GRB14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GRB14 antibodies...

We validate the specificity of these antibodies to GRB14 by testing them on tissues known to express GRB14 positively and negatively. Browse below to find the GRB14 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GRB14 Infographic by Boster Bio

All GRB14 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-GRB14 (D123) Antibody

Human, Mouse, Rat

IHC

$405
Cat # A04177
100ul

Anti-GRB14 Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A04177-1
100ul

Anti-GRB14 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A04177-2
100 μg/vial

GRB 14 (GRB14) (NM_004490) Human Over-expression Lysate

Human

$960
Cat # LS002888
100 µg

GRB14 Overview

Facts about Growth factor receptor-bound protein 14.

GRB14 3D structure. Source: alphafold

Growth factor receptor-bound protein 14 (GRB14)

Adapter protein that modulates coupling of cell surface receptor kinases with particular signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR).

Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Gene Information

Human
Gene Name:	GRB14
Uniprot:	Q14449
Entrez:	2888

Family

Belongs to:

GRB7/10/14 family

Alternative Names

Growth factor receptor-bound protein 14

Molecular Weight

Mass (kDA):
60.988 kDA

Genomic Context


Human

Location:	2q24.3
Sequence:	2; NC_000002.12 (164492417..164622959, complement)

Tissue Specificity

Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.

Subcellular Localizations

Cytoplasm. Endosome membrane; Peripheral membrane protein. Upon insulin stimulation, translocates to the plasma membrane.

PTMs

Acetylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRB14

References

PMID: 8647858 by Daly R.J., et al. Cloning and characterization of GRB14, a novel member of the GRB7 gene family.

PMID: 11726652 by Bereziat V., et al. Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.