RAPGEF1 Antibodies

AND RAPGEF1 ELISA kits, RAPGEF1 Proteins

Many biological assays use antibodies to detect RAPGEF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAPGEF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAPGEF1 antibodies...

We validate the specificity of these antibodies to RAPGEF1 by testing them on tissues known to express RAPGEF1 positively and negatively. Browse below to find the RAPGEF1 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RAPGEF1 Infographic by Boster Bio

All RAPGEF1 Products

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Product

Figures

Specificity

Applications

Price

Anti-Phospho RapGEF1 (Tyr504) Antibody

1 Q&As

Human, Mouse, Rat

ELISA, IHC-P, WB, IF (paraffin)

$335
Cat # P06527
100ul

Anti-RapGEF1/Grf2 Antibody

3 Q&As

Human, Mouse, Rat

ELISA, IHC-P, IF (paraffin)

$335
Cat # A06527
100ul

Anti-Phospho-C3G (Y504) RAPGEF1 Antibody

Human

ELISA, WB

$380
Cat # A06527Y504
100ul

Anti-RAPGEF1 Antibody (Center)

Human

$299
Cat # M06527
80 µl

Anti-GRF2 (RAPGEF1) Mouse Monoclonal Antibody [Clone ID: OTI2F5]

Dog, Human, Monkey, Mouse, Rat

IF, IHC, WB

$523
Cat # M06527-1
100 µl

GRF2 (RAPGEF1) (NM_198679) Human Over-expression Lysate

Human

$628
Cat # LS002889
100 µg

RAPGEF1 Overview

Facts about Rap guanine nucleotide exchange factor 1.

RAPGEF1 3D structure. Source: alphafold

Rap guanine nucleotide exchange factor 1 (RAPGEF1)

Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS.

Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.

Gene Information

Human
Gene Name:	RAPGEF1
Uniprot:	Q13905
Entrez:	2889

Family

Belongs to:

No superfamily

Alternative Names

C3GGRF2guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene); CRK SH3-binding GNRP; DKFZp781P1719; Guanine nucleotide-releasing factor 2; Protein C3G; Rap guanine nucleotide exchange factor (GEF) 1; rap guanine nucleotide exchange factor 1

Molecular Weight

Mass (kDA):
120.548 kDA

Genomic Context


Human

Location:	9q34.13
Sequence:	9; NC_000009.12 (131576770..131740076, complement)

Tissue Specificity

Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver.

Subcellular Localizations

Early endosome.

Diseases

Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Carcinoma
Malignant Neoplasms
Neoplasms
Neuroblastoma
Tissue Adhesions
Epilepsy
Genital Neoplasms, Female
Juvenile Neuronal Ceroid Lipfuscinosis
Malignant Neoplasm Of Breast
Neurodegenerative Disorders
Malignant Tumor Of Colon

Gastrointestinal Neoplasms
Myeloid Leukemia, Chronic
Neoplasm Invasiveness
Malignant Neoplasm Of Lung
Insulin Resistance
Pyotraumatic Dermatitis
Myeloid Leukemia

Interacting Proteins

ABL1
CRK
CRKL
FYN
NCK1

PIK3R1
SRC

Pathways

Methylation
Cell Adhesion
Neuron Migration
Golgi Localization
Cell Proliferation
Cell Cycle
Cell Death
Cellular Homeostasis
Dna Methylation

Pathogenesis
Localization
Demethylation

PTMs

Phosphorylation
Dephosphorylation

Demethylation
Methylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAPGEF1

References

PMID: 7512734 by Tanaka S., et al. C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.

PMID: 7806500 by Knudsen B., et al. Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk.