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GPS1 Antibodies
AND GPS1 ELISA kits, GPS1 Proteins
Many biological assays use antibodies to detect GPS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPS1 antibodies...
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GPS1 Overview
Facts about COP9 signalosome complex subunit 1.
COP9 signalosome complex subunit 1 (GPS1)
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2.
The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN protects and promotes degradation from the Ubl system, respectively.
Gene Information
| Human | |
|---|---|
| Gene Name: | GPS1 |
| Uniprot: | Q13098 |
| Entrez: | 2873 |
Family
| Belongs to: |
|---|
| CSN1 family |
Alternative Names
COP9 signalosome complex subunit 1; COPS1JAB1-containing signalosome subunit 1; CSN1MGC71287; G protein pathway suppressor 1SGN1; GPS-1; Protein MFH; Signalosome subunit 1
Molecular Weight
Mass (kDA):
55.537 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.3 |
| Sequence: | 17; NC_000017.11 (82051465..82058064) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Neoplasm Metastasis
- Metastatic Malignant Neoplasm To The Lymph Node
- Malignant Neoplasms
- Neoplasms
- Esophageal Neoplasms
- Schizophrenia
- Hepatocarcinogenesis
- Liver Neoplasms, Experimental
- Idiopathic Pulmonary Hypertension
- Non-neoplastic Disorder
- Metastatic Malignant Neoplasm To The Liver
- Lung Diseases
Interacting Proteins
- COPS2
- COPS5
- COPS8
Pathways
- Photomorphogenesis
- Localization
- Cell Cycle
- Transport
- Proteolysis
- Embryo Development
- Auxin Transport
- Basipetal Auxin Transport
- Flower Development
- Response To Gravity
- Cell Cycle Arrest
- Spermatogenesis
- Protein Glycosylation
PTMs
- Phosphorylation
- Reduction
Research Areas
- Cell Cycle and Replication
- Neuronal Cell Markers
- Neurotransmission
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPS1
bosterbio.com/bosterbio-gene-info-cards/GPS1
References
PMID: 8943324 by Spain B.H., et al. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells.
PMID: 9535219 by Seeger M., et al. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.