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GPS2 Antibodies
AND GPS2 ELISA kits, GPS2 Proteins
Many biological assays use antibodies to detect GPS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPS2 antibodies...
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GPS2 Overview
Facts about G protein pathway suppressor 2.
G protein pathway suppressor 2 (GPS2)
Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of this ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:24943844).
Acts as a transcription coactivator in adipocytes by encouraging the recruitment of PPARG to promoters: functions by inhibiting the activity of this ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator (PubMed:19481530).
Gene Information
| Human | |
|---|---|
| Gene Name: | GPS2 |
| Uniprot: | Q13227 |
| Entrez: | 2874 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AMF-1; G protein pathway suppressor 2; GPS-2; MGC104294; MGC119287; MGC119288; MGC119289
Molecular Weight
Mass (kDA):
36.689 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17p13.1 |
| Sequence: | 17; NC_000017.11 (7312661..7315360, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Nucleus. Mitochondrion. Cytoplasm, cytosol. Sumoylation regulates the subcellular location (PubMed:24943844). Relocates from the mitochondria to the nucleus following desumoylation, leading to mediate mitochondrial stress response (By similarity).
Diseases
- Malignant Neoplasms
- Inflammation
- Neoplasms
- Neoplasm Metastasis
- Metastatic Malignant Neoplasm To The Lymph Node
- Esophageal Neoplasms
- Hepatocarcinogenesis
- Obesity
- Papilloma
- Moderate Mental Retardation
- Melanoma
- Malignant Neoplasm Of Breast
Interacting Proteins
- ATF4
- HDAC1
- HDAC3
- KRT31
- MAP3K7CL
- RALBP1
- RBPMS
- SESTD1
- TFIP11
Pathways
- Cell Cycle
- Meiosis
- Dna Repair
- Cell Growth
- Transport
- Programmed Cell Death
- Brain Development
- Cell Cycle Arrest
- Spermatogenesis
- Protein Glycosylation
- Mrna Splicing
- Cholesterol Efflux
- Centrosome Duplication
PTMs
- Sumoylation
- Demethylation
- Phosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPS2
bosterbio.com/bosterbio-gene-info-cards/GPS2
References
PMID: 8943324 by Spain B.H., et al. Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells.
PMID: 11931768 by Zhang J., et al. The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.