G protein pathway suppressor 2 (GPS2)

Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of this ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:24943844).

Acts as a transcription coactivator in adipocytes by encouraging the recruitment of PPARG to promoters: functions by inhibiting the activity of this ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator (PubMed:19481530).