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- Table of Contents
Facts about G-protein coupled receptor 61.
Reveals a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). Might be involved in the regulation of food intake and body weight (By similarity).
Human | |
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Gene Name: | GPR61 |
Uniprot: | Q9BZJ8 |
Entrez: | 83873 |
Belongs to: |
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G-protein coupled receptor 1 family |
BALGR; BALGRBiogenic amine receptor-like G-protein coupled receptor; biogenic amine receptor-like GPCR; G protein-coupled receptor 61; GPCR3; GPR61; probable G-protein coupled receptor 61
Mass (kDA):
49.292 kDA
Human | |
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Location: | 1p13.3 |
Sequence: | 1; NC_000001.11 (109539872..109545848) |
Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus (PubMed:11690637, PubMed:29226084). Also expressed in testis (PubMed:11690637, PubMed:29226084) and T cells, B cells, and monocyte (PubMed:29226084). Low expression in many other tissues (PubMed:11690637, PubMed:29226084). Widely expressed in the hippocampus (at protein level).
Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Colocalizes with ARRB2/beta-arrestin-2 in the endosome (PubMed:28827538).
PMID: 11165367 by Lee D.K., et al. Identification of four novel human G protein-coupled receptors expressed in the brain.
PMID: 11690637 by Cikos S., et al. Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain.