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- Table of Contents
Facts about Neuronal membrane glycoprotein M6-a.
GPM6A-induced filopodia formation entails mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx.
Human | |
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Gene Name: | GPM6A |
Uniprot: | P51674 |
Entrez: | 2823 |
Belongs to: |
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myelin proteolipid protein family |
glycoprotein M6A; GPM6A; M6A; M6AGPM6; neuronal membrane glycoprotein M6-a
Mass (kDA):
31.21 kDA
Human | |
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Location: | 4q34.2 |
Sequence: | 4; NC_000004.12 (175632937..176002691, complement) |
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, growth cone. Cell projection, dendritic spine. Cell projection, filopodium. Cell projection, neuron projection. Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons (By similarity). Localized to the growth cone edge membrane of elongating axons (By similarity).
PMID: 8893821 by Shimizu F., et al. Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34.
PMID: 8661015 by Olinsky S., et al. Chromosomal mapping of the human M6 genes.