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- Table of Contents
Facts about Neuronal membrane glycoprotein M6-b.
Involved in matrix vesicle discharge by osteoblasts; this purpose seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.
Human | |
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Gene Name: | GPM6B |
Uniprot: | Q13491 |
Entrez: | 2824 |
Belongs to: |
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myelin proteolipid protein family |
glycoprotein M6B; M6b; M6Bneuronal membrane glycoprotein M6-b; MGC17150; MGC54284; protolipid M6B
Mass (kDA):
28.989 kDA
Human | |
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Location: | Xp22.2 |
Sequence: | X; NC_000023.11 (13770922..13938824, complement) |
Neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia.
Cell membrane; Multi-pass membrane protein. Colocalizes with SERT at the plasma membrane.
PMID: 8661015 by Olinsky S., et al. Chromosomal mapping of the human M6 genes.
PMID: 9674909 by Narayanan V., et al. Mutation analysis of the M6b gene in patients with Rett syndrome.