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- Table of Contents
Facts about G-protein coupled bile acid receptor 1.
May be involved in the suppression of macrophage functions by bile acids. .
Human | |
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Gene Name: | GPBAR1 |
Uniprot: | Q8TDU6 |
Entrez: | 151306 |
Belongs to: |
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G-protein coupled receptor 1 family |
BG37; BG37hBG37; G protein-coupled bile acid receptor 1; GPBA; GPBAR1; GPCR19; GPR131; G-protein coupled bile acid receptor 1; G-protein coupled bile acid receptor BG37; G-protein coupled receptor GPCR19; M-BAR; M-BARhGPCR19; membrane bile acid receptor; Membrane-type receptor for bile acids; MGC40597; TGR5; TGR5GPCR
Mass (kDA):
35.248 kDA
Human | |
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Location: | 2q35 |
Sequence: | 2; NC_000002.12 (218259496..218263861) |
Ubiquitously expressed. Expressed at higher level in spleen and placenta. Expressed at lower level in other tissues. In digestive tissues, it is expressed in stomach, duodenum, ileocecum, ileum, jejunum, ascending colon, transverse colon, descending colon, cecum and liver, but not in esophagus and rectum.
Cell membrane; Multi-pass membrane protein.
PMID: 12419312 by Maruyama T., et al. Identification of membrane-type receptor for bile acids (M-BAR).
PMID: 12524422 by Kawamata Y., et al. A G protein-coupled receptor responsive to bile acids.