GPATCH3 Antibodies

AND GPATCH3 ELISA kits, GPATCH3 Proteins

Many biological assays use antibodies to detect GPATCH3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPATCH3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPATCH3 antibodies...

We validate the specificity of these antibodies to GPATCH3 by testing them on tissues known to express GPATCH3 positively and negatively. Browse below to find the GPATCH3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: NAPB

GPATCH3 Infographic by Boster Bio

All GPATCH3 Products

Product

Figures

Specificity

Applications

Price

GPATCH3 (NM_022078) Human Recombinant Protein

$1249
Cat # PROTQ96I76
20 µg

GPATCH3 (NM_022078) Human Over-expression Lysate

Human

$628
Cat # LS063906
100 µg

GPATCH3 Overview

Facts about G patch domain-containing protein 3.

GPATCH3 3D structure. Source: alphafold

G patch domain-containing protein 3 (GPATCH3)

Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it may control neural crest cell migration involved with ocular and craniofacial growth (PubMed:28397860).

Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS meeting with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6 (PubMed:28414768).

Gene Information

Human
Gene Name:	GPATCH3
Uniprot:	Q96I76
Entrez:	63906

Family

Belongs to:

No superfamily

Alternative Names

DKFZp686E0221; FLJ12455; G patch domain containing 3; G patch domain-containing protein 3; GPATC3

Molecular Weight

Mass (kDA):
59.338 kDA

Genomic Context


Human

Location:	1p36.11
Sequence:	1; NC_000001.11 (26890488..26900467, complement)

Tissue Specificity

Expressed in ocular tissues including retinal pigment epithelium, cornea, ciliary muscle and non-pigmented ciliary epithelium. Also expressed in optic nerve, cartilage, skin and lymph node.

Subcellular Localizations

Nucleus. Cytoplasm.

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPATCH3

References

PMID: 28414768 by Nie Y., et al. GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome.

PMID: 28397860 by Ferre-Fernandez J.J., et al. Whole-exome sequencing of congenital glaucoma patients reveals hypermorphic variants in GPATCH3, a new gene involved in ocular and craniofacial development.