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- Table of Contents
, No Gclids
GOPC Antibodies
AND GOPC ELISA kits, GOPC Proteins
Many biological assays use antibodies to detect GOPC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GOPC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GOPC antibodies...
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GOPC Infographic by Boster Bio
All GOPC Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M03660-1
100 μl/vial
Cat # M03660-1
100 μl/vial
GOPC Overview
Facts about Golgi-associated PDZ and coiled-coil motif-containing protein.
Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC)
Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels.
May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy.
Gene Information
| Human | |
|---|---|
| Gene Name: | GOPC |
| Uniprot: | Q9HD26 |
| Entrez: | 57120 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CALPDZ protein interacting specifically with TC10; CFTR-associated ligand; dJ94G16.2; FIGdJ94G16.2 PIST; Fused in glioblastoma; golgi-associated PDZ and coiled-coil motif containing; Golgi-associated PDZ and coiled-coil motif-containing protein; GOPC1; PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10; PISTGolgi associated PDZ and coiled-coil motif containing protein
Molecular Weight
Mass (kDA):
50.52 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q22.1 |
| Sequence: | 6; NC_000006.12 (117560269..117602520, complement) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Cell projection, dendrite. Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.
Diseases
- Cystic Fibrosis
- Fibrosis
- Infertility
- Male Infertility
- Nerve Degeneration
- Tissue Adhesions
- Diabetes Mellitus
- Nervousness
- Neoplasms
- Influenza
- Pancreatitis
- Cell Invasion
- Hypertensive Disease
Interacting Proteins
- AKIRIN1
- BATF
- C17orf67
- CCDC102B
- DPYD
- FAM90A1
- FOSL2
- HCK
- JUN
- LCLAT1
Pathways
- Autophagy
- Localization
- Transport
- Golgi Localization
- Cell Death
- Fertilization
- Endocytic Recycling
- Endocytosis
- Spermatogenesis
- Clathrin-mediated Endocytosis
- Cell Adhesion
- Intracellular Transport
- Secretory Pathway
PTMs
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GOPC
bosterbio.com/bosterbio-gene-info-cards/GOPC
References
PMID: 11162552 by Neudauer C.L., et al. PIST: a novel PDZ/coiled-coil domain binding partner for the rho- family GTPase TC10.
PMID: 11384996 by Charest A., et al. Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6.