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- Table of Contents
Facts about Glutamine synthetase.
Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: functions by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707).
Human | |
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Gene Name: | GLUL |
Uniprot: | P15104 |
Entrez: | 2752 |
Belongs to: |
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glutamine synthetase family |
cell proliferation-inducing protein 59; EC 4.1.1.15; EC 6.3.1.2; GLNSPIG59; Glutamate decarboxylase; glutamate-ammonia ligase (glutamine synthase); glutamate-ammonia ligase; Glutamate--ammonia ligase; glutamine synthase; glutamine synthetase; GS; PIG43; proliferation-inducing protein 43
Mass (kDA):
42.064 kDA
Human | |
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Location: | 1q25.3 |
Sequence: | 1; NC_000001.11 (182378093..182392206, complement) |
Expressed in endothelial cells.
Cytoplasm, cytosol. Microsome. Mitochondrion. Cell membrane; Lipid-anchor. Mainly localizes in the cytosol, with a fraction associated with the cell membrane.
PMID: 2888076 by Gibbs C.S., et al. Sequence of a human glutamine synthetase cDNA.
PMID: 1681907 by van den Hoff M.J.B., et al. cDNA sequence of the long mRNA for human glutamine synthase.