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- Table of Contents
Facts about Ganglioside GM2 activator.
It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules out of membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3.
Human | |
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Gene Name: | GM2A |
Uniprot: | P17900 |
Entrez: | 2760 |
Belongs to: |
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No superfamily |
Cerebroside sulfate activator protein; ganglioside GM2 activator; GM2 ganglioside activator; GM2-AP; SAP-3GM2 ganglioside activator protein; Shingolipid activator protein 3; sphingolipid activator protein 3
Mass (kDA):
20.838 kDA
Human | |
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Location: | 5q33.1 |
Sequence: | 5; NC_000005.10 (151253185..151270440) |
Lysosome.
PMID: 2059210 by Xie B., et al. Isolation and expression of a full-length cDNA encoding the human G- M2 activator protein.
PMID: 1915857 by Klima H., et al. Characterization of full-length cDNAs and the gene coding for the human GM2 activator protein.