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GGA3 Antibodies
AND GGA3 ELISA kits, GGA3 Proteins
Many biological assays use antibodies to detect GGA3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GGA3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GGA3 antibodies...
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GGA3 Infographic by Boster Bio
All GGA3 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03641-2
100 μg/vial
Cat # A03641-2
100 μg/vial
GGA3 Overview
Facts about ADP-ribosylation factor-binding protein GGA3.
ADP-ribosylation factor-binding protein GGA3 (GGA3)
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules using a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005).
Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). Nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:17553422, PubMed:15615712, PubMed:20484053).
Gene Information
| Human | |
|---|---|
| Gene Name: | GGA3 |
| Uniprot: | Q9NZ52 |
| Entrez: | 23163 |
Family
| Belongs to: |
|---|
| GGA protein family |
Alternative Names
ADP-ribosylation factor-binding protein GGA3; golgi associated, gamma adaptin ear containing, ARF binding protein 3; golgi-associated, gamma adaptin ear containing, ARF binding protein 3; KIAA0154Golgi-localized, gamma ear-containing, ARF-binding protein 3
Molecular Weight
Mass (kDA):
78.315 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.1 |
| Sequence: | 17; NC_000017.11 (75225464..75262363, complement) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein.
Diseases
- Alzheimer's Disease
- Cerebral Ischemia
- Ischemia
- Diabetes Mellitus
- Brain Ischemia
- Craniocerebral Trauma
- Juvenile Neuronal Ceroid Lipfuscinosis
- Infarction
- Occlusion, Middle Cerebral Artery
- Brain Infarction
- Malignant Neoplasms
- Neoplasm/cancer Invasiveness
Interacting Proteins
- ARF6
- BACE1
- GGA1
- GGA2
- IGF2R
- PACS1
- RABEP1
- UBB
Pathways
- Transport
- Pathogenesis
- Intracellular Transport
- Immune Response
- Endocytosis
- Rna Interference
- Cell Migration
- Humoral Immune Response
- Secretion
- Vesicle Transport
- Cell Proliferation
- Endocytic Recycling
- Macropinocytosis
PTMs
- Ribosylation
- Phosphorylation
Research Areas
- Cell Biology
- Golgi Apparatus Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GGA3
bosterbio.com/bosterbio-gene-info-cards/GGA3
References
PMID: 10747089 by Dell'Angelica E.C., et al. GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex.
PMID: 10749927 by Boman A.L., et al. A family of ADP-ribosylation factor effectors that can alter transport through the trans-Golgi.