GFRA2 Antibodies

GDNF family receptor alpha-2 (GFRA2)

Receptor for neurturin.

Mediates the NRTN-induced autophosphorylation and activation of the RET receptor.

Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. .

Gene Information

Human
Gene Name:	GFRA2
Uniprot:	O00451
Entrez:	2675

Family

Belongs to:
GDNFR family

Alternative Names

GDNF family receptor alpha 2; GDNF family receptor alpha-2; GDNF R alpha-2; GDNF receptor alpha-2; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GDNFRBRET ligand 2; GFR alpha2; GFR alpha-2; GFRA2; GFRa-2; GFR-alpha 2; GFR-alpha-2; glial cell line derived neurotrophic factor receptor, beta; Neurturin receptor alpha; NRTNR-alpha; NTNRA; NTNR-alpha; PI-linked cell-surface accessory protein; RETL2TGF-beta-related neurotrophic factor receptor 2; TGF-beta related neurotrophic factor receptor 2; TRN receptor, GPI-anchored; TRNR2NRTNR-ALPHA

Molecular Weight

Mass (kDA):
51.544 kDA

Genomic Context

Human
Location:	8p21.3
Sequence:	8; NC_000008.11 (21690398..21789296, complement)

Tissue Specificity

Isoform 1 is found in both brain and placenta.

Subcellular Localizations

Cell membrane; Lipid-anchor, GPI-anchor.

Diseases

• Nervousness
• Neoplasms
• Pituitary Diseases
• Thyroid Neoplasm
• Nerve Damage
• Malignant Neoplasm Of Thyroid
• Malnutrition
• Carcinoma
• Pain
• Ischemia
• Epilepsy
• Malignant Neoplasms

• Congenital Absence
• Medullary Carcinoma Of Thyroid
• Parkinson Disease
• Schizophrenia
• Brain Ischemia
• Retinal Degeneration

Pathways

• Innervation
• Localization
• Regeneration
• Cell Death
• System Development
• Nervous System Development
• Secretion
• Programmed Cell Death
• Enteric Nervous System Development
• Pathogenesis
• Cell Adhesion
• Cell Proliferation
• Cell Activation

• Catagen
• Brain Development
• Aging
• Cytokine Secretion
• Neurogenesis
• Regulation Of Programmed Cell Death
• Inflammatory Response

PTMs

• Phosphorylation

• Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GFRA2

Boster Bio - Best Uses Of The GFRA2 Marker

This article will help you optimize your experiments using the GFRA2 marker. This article will cover Boster Bio's GFRA2 marker, High-affinity primary antibodies, and optimization tips. Continue reading for more information! In no time you will be able inform yourself about your experiments. So, how can you best use this marker?

Boster Bio: GFRA2 Marker

The GFRA2 markers regulate the activity of cells within the immune system. The GFRA2 indicator also includes many other genes. This gene could be used to replace IL33. GFRA2 also expresses in IL33.

Primary antibodies of high-affinity

The GFRA2 marker is a highly relevant target for the development of high-affinity primary antibodies for glioma. This marker can be found on many cellular structures, including glial cells. High-affinity antibody forms ligand/antibody bonds with a KD of between 10 and 5 mg. This target is also blocked by antibodies.

There are many genes that can be found in basket cells. A few of these include Adamts15, March21, Tfap2b and Tfap2a. These markers are ordered by decreasing specificity. You can use this marker to create an antibody that will specifically recognize both these genes. High-affinity antibodies will be effective in treating glioma.