GFER Antibodies

AND GFER ELISA kits, GFER Proteins

Many biological assays use antibodies to detect GFER, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GFER in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GFER antibodies...

We validate the specificity of these antibodies to GFER by testing them on tissues known to express GFER positively and negatively. Browse below to find the GFER antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GFER Infographic by Boster Bio

All GFER Products

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Product

Figures

Specificity

Applications

Price

Anti-ALR GFER Antibody

5 Q&As

Human, Mouse, Rat

IHC, WB

$399
Cat # A03595
100μl

ALR (GFER) (NM_005262) Human Recombinant Protein

$813
Cat # PROTP55789
20 µg

ALR (GFER) (NM_005262) Human Over-expression Lysate

Human

$628
Cat # LS002671
100 µg

GFER Overview

Facts about FAD-linked sulfhydryl oxidase ALR.

GFER 3D structure. Source: alphafold

FAD-linked sulfhydryl oxidase ALR (GFER)

Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, leading to regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes oxidized by donating electrons to cytochrome c or molecular oxygen.

Gene Information

Human
Gene Name:	GFER
Uniprot:	P55789
Entrez:	2671

Family

Belongs to:

No superfamily

Alternative Names

ALR; ALRFAD-linked sulfhydryl oxidase ALR; Augmenter of liver regeneration; EC 1.8.3.2; ERV1 homolog; ERV1; ERV1hepatopoietin protein; erv1-like growth factor; GFER; growth factor, augmenter of liver regeneration; growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration); Hepatopoietin; HERV1; HERV1hepatic regenerative stimulation substance; HPO; HPO1; HPO2; HSS; truncated augmenter of liver regeneration

Molecular Weight

Mass (kDA):
23.449 kDA

Genomic Context


Human

Location:	16p13.3
Sequence:	16; NC_000016.10 (1984193..1987749)

Tissue Specificity

Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle.

Subcellular Localizations

[Isoform 1]: Mitochondrion intermembrane space. Mitochondrion.; [Isoform 2]: Cytoplasm. Secreted.

Diseases

Liver Regeneration Disorder
Malignant Neoplasms
Liver Carcinoma
Liver Neoplasms
Mitochondrial Diseases
Carcinoma
Neoplasms
Liver Failure
Myopathy
Injury To Liver
Cataract
Liver Cirrhosis
Neuroblastoma

Liver Failure, Acute
Cholangiocarcinoma
Mitochondrial Dna Depletion
Neoplasm Metastasis
Non-neoplastic Disorder
Bile Duct Neoplasms
Neoplasms, Experimental

Interacting Proteins

PLEKHF2

Pathways

Regeneration
Liver Regeneration
Hepatocyte Proliferation
Cell Proliferation
Localization
Protein Folding
Transport
Electron Transport
Electron Transport Chain
Mitochondrial Fission
Pathogenesis
Cell Migration
Protein Maturation

Proteolysis
Nuclear Export
Conjugation
Release Of Cytochrome C From Mitochondria
Sensitization
Cell Cycle
Cell Death

PTMs

Reduction
Oxidation

Phosphorylation
Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GFER

References

PMID: 10712775 by Cheng J., et al. Cloning and sequence analysis of human genomic DNA of augmenter of liver regeneration hepatitis.

PMID: 8575761 by Lisowsky T., et al. A new human gene located in the PKD1 region of chromosome 16 is a functional homologue to ERV1 of yeast.