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- Table of Contents
Facts about Gem-associated protein 8.
Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP.
Human | |
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Gene Name: | GEMIN8 |
Uniprot: | Q9NWZ8 |
Entrez: | 54960 |
Belongs to: |
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No superfamily |
FAM51A1; FLJ43072; gem (nuclear organelle) associated protein 8; gemin-8; member A1; Protein FAM51A1
Mass (kDA):
28.637 kDA
Human | |
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Location: | Xp22.2 |
Sequence: | X; NC_000023.11 (14002494..14029918, complement) |
Nucleus, gem. Cytoplasm. Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
PMID: 16434402 by Carissimi C., et al. Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly.
PMID: 17023415 by Carissimi C., et al. Gemin8 is required for the architecture and function of the survival motor neuron complex.