GCNT1 Antibodies

AND GCNT1 ELISA kits, GCNT1 Proteins

Many biological assays use antibodies to detect GCNT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GCNT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GCNT1 antibodies...

We validate the specificity of these antibodies to GCNT1 by testing them on tissues known to express GCNT1 positively and negatively. Browse below to find the GCNT1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GCNT1 Infographic by Boster Bio

All GCNT1 Products

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Specificity

Applications

Price

GCNT1 (NM_001097634) Human Over-expression Lysate

Human

$960
Cat # LS002650
100 µg

Human GCNT1 ELISA Kit PicoKine®

Human

ELISA

$750
Cat # EK2204
96 wells/kit, with removable strips.

GCNT1 Overview

Facts about Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase.

GCNT1 3D structure. Source: alphafold

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1)

Glycosyltransferase that catalyzes the transfer of an N- acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O- glycans play an significant role in leukocyte extravasation since they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes.

Gene Information

Human
Gene Name:	GCNT1
Uniprot:	Q02742
Entrez:	2650

Family

Belongs to:

glycosyltransferase 14 family

Alternative Names

beta-1,3-galactosyl-O-glycosyl-glycoproteinbeta-1,6-N-acetylglucosaminyltransferase; beta-1,6-N-acetylglucosaminyltransferase; C2GNT1; C2GNTbeta-1,3-galactosyl-O-glycosyl-glycoproteinbeta-1,6-N--acetylglucosaminyltransferase; C2GNT-L; core 2 beta1,6 N-acetylglucosaminyltransferase-I; core 2 beta-1,6-N-acetylglucosaminyltransferase I; core 2 branching enzyme; Core 2 GNT; Core 2-branching enzyme; core2-GlcNAc-transferase; EC 2.4.1.102; G6NT; GCNT1; glucosaminyl (N-acetyl) transferase 1, core 2; glucosaminyl (N-acetyl) transferase 1, core 2(beta-1,6-N-acetylglucosaminyltransferase); MGC126335; MG

Molecular Weight

Mass (kDA):
49.799 kDA

Genomic Context


Human

Location:	9q21.13
Sequence:	9; NC_000009.12 (76441666..76507416)

Tissue Specificity

Highly expressed in activated T-lymphocytes and myeloid cells.

Subcellular Localizations

Golgi apparatus membrane; Single-pass type II membrane protein. Also detected in the trans-Golgi network.

Diseases

Cell Invasion
Single Tumor
Malignant Neoplasms
Severe Combined Immunodeficiency
Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms

Neoplasm Invasiveness
Mammary Neoplasms, Experimental

Interacting Proteins

GOLPH3

PTMs

Disulfide bond

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GCNT1

References

PMID: 1329093 by Bierhuizen M.F.A., et al. Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc- R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen.

PMID: 7579796 by Bierhuizen M.F.A., et al. Genomic organization of core 2 and I branching beta-1,6-N- acetylglucosaminyltransferases. Implication for evolution of the beta- 1,6-N-acetylglucosaminyltransferase gene family.