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- Table of Contents
Facts about Non-lysosomal glucosylceramidase.
May also catalyze the hydrolysis of bile acid 3-O-glucosides, however, the relevance of such action is unclear in vivo. Plays a role in central nevous system development.
Human | |
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Gene Name: | GBA2 |
Uniprot: | Q9HCG7 |
Entrez: | 57704 |
Belongs to: |
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non-lysosomal glucosylceramidase family |
AD035; Beta-glucocerebrosidase 2; Beta-glucosidase 2; bile acid beta-glucosidase; DKFZp762K054; glucosidase, beta (bile acid) 2; Glucosylceramidase 2; KIAA1605EC 3.2.1.45; MGC16895; NLGase; non-lysosomal glucosylceramidase
Mass (kDA):
104.649 kDA
Human | |
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Location: | 9p13.3 |
Sequence: | 9; NC_000009.12 (35736862..35749228, complement) |
Widely expressed. Highly expressed in brain, heart, skeletal muscle, kidney and placenta and expressed at lower level in liver.
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Localization to the plasma membrane and alternative topologies have also been reported.
PMID: 11489889 by Matern H., et al. Molecular cloning and expression of human bile acid beta -glucosidase.
PMID: 9111029 by Matern H., et al. Purification and characterization of a microsomal bile acid beta- glucosidase from human liver.