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- Table of Contents
Facts about Polypeptide N-acetylgalactosaminyltransferase 2.
Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region. .
Human | |
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Gene Name: | GALNT2 |
Uniprot: | Q10471 |
Entrez: | 2590 |
Belongs to: |
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glycosyltransferase 2 family |
GalNAc-T2; GalNAc-T2EC 2.4.1.41; GALNT2; Polypeptide GalNac Transferase 2; polypeptide N-acetylgalactosaminyltransferase 2; pp-GaNTase 2; Protein-UDP acetylgalactosaminyltransferase 2; UDP-GalNAc transferase 2; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2; UDP-N-acetyl-alpha-D-galactosamine:polypeptideN-acetylgalactosaminyltransferase 2 (GalNAc-T2)
Mass (kDA):
64.733 kDA
Human | |
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Location: | 1q42.13 |
Sequence: | 1; NC_000001.11 (230057789..230282122) |
Widely expressed.
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.
PMID: 7592619 by White T., et al. Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D- galactosamine:polypeptide N-acetylgalactosaminyltransferase.
PMID: 9295285 by Wandall H.H., et al. Substrate specificities of three members of the human UDP-N-acetyl- alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.