UDP-glucose 4-epimerase Antibodies

AND GALE ELISA kits, UDP-glucose 4-epimerase Proteins

Many biological assays use antibodies to detect UDP-glucose 4-epimerase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with UDP-glucose 4-epimerase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop UDP-glucose 4-epimerase antibodies...

We validate the specificity of these antibodies to UDP-glucose 4-epimerase by testing them on tissues known to express GALE positively and negatively. Browse below to find the GALE antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GALE Infographic by Boster Bio

All GALE Products

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Specificity

Applications

Price

Anti-GALE Antibody Picoband®

1 Q&As

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A00551-1
100 μg/vial

GALE (NM_000403) Human Recombinant Protein

$813
Cat # PROTQ14376
20 µg

Anti-GALE Mouse Monoclonal Antibody [Clone ID: OTI1C4]

Dog, Human, Monkey, Mouse, Rat

IHC, WB

$523
Cat # M00551
100 µl

GALE Overview

Facts about UDP-glucose 4-epimerase.

GALE 3D structure. Source: alphafold

UDP-glucose 4-epimerase (GALE)

Catalyzes two different but analogous responses: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The response with UDP-Gal plays a crucial role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6- phosphate.

It contributes to the catabolism of dietary galactose and empowers the endogenous biosynthesis of both UDP-Gal and UDP- GalNAc when exogenous resources are limited. The two UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.

Gene Information

Human
Gene Name:	GALE
Uniprot:	Q14376
Entrez:	2582

Family

Belongs to:

NAD(P)-dependent epimerase/dehydratase family

Alternative Names

EC 5.1.3; EC 5.1.3.2; FLJ95174; FLJ97302; Galactowaldenase; short chain dehydrogenase/reductase family 1E, member 1; UDP galactose-4'-epimerase; UDP-; UDP-galactose 4-epimerase; UDP-galactose-4-epimerase; UDP-glucose 4-epimerase

Molecular Weight

Mass (kDA):
38.282 kDA

Genomic Context


Human

Location:	1p36.11
Sequence:	1; NC_000001.11 (23795599..23800754, complement)

Diseases

Udpglucose 4-epimerase Deficiency Disease
Salmonella Infections
Classical Galactosemia
Deficiency Of Galactokinase
Galactosemias
Influenza
Tissue Adhesions
Deficiency Of Epimerase
Typhoid Fever
Malignant Neoplasms
Diabetes Mellitus, Insulin-dependent
Inborn Errors Of Metabolism
Cell Invasion

Guillain-barre Syndrome
Pneumonia
Cholera
Abscess
Cancer Patients And Suicide And Depression
Meningococcal Infections
Group B Streptococcal Infection

Pathways

Virulence
Transport
Translation
Glycosylation
Biofilm Formation
Localization
Cell Proliferation
Pathogenesis
Excretion
Immune Response
Nodulation
Locomotion
Colony Morphology

Cell Division
Nitrogen Fixation
Lactose Transport
Germination
Proteolysis
Complement Activation
Seed Germination

PTMs

Glycosylation
Methylation
Deglycosylation
Phosphorylation

Cleavage
Oxidation
Nitration
Dephosphorylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GALE

References

PMID: 8593531 by Daude N., et al. Molecular cloning, characterization, and mapping of a full-length cDNA encoding human UDP-galactose 4'-epimerase.

PMID: 9538513 by Maceratesi P., et al. Human UDP-galactose 4'epimerase (GALE) gene and identification of five missense mutations in patients with epimerase deficiency galactosemia.