GABRA1 Antibodies

Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1)

Part of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine.

Functions as receptor for diazepines and various anesthetics, such as pentobarbital; those are bound at a different allosteric effector binding site. Functions as ligand- gated chloride channel (By similarity).

Gene Information

Human
Gene Name:	GABRA1
Uniprot:	P14867
Entrez:	2554

Family

Belongs to:
ligand-gated ion channel (TC 1.A.9) family

Alternative Names

ECA4; EJM; EJM5GABA(A) receptor subunit alpha-1; GABA A R alpha 1; GABAAR alpha 1; GABAARa1; GABRA1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid receptor subunit alpha-1

Molecular Weight

Mass (kDA):
51.802 kDA

Genomic Context

Human
Location:	5q34
Sequence:	5; NC_000005.10 (161847191..161899971)

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.

Diseases

• Epilepsy
• Epilepsy, Generalized
• Epilepsies, Myoclonic
• Myoclonic Epilepsy, Juvenile
• Nervousness
• Absence Epilepsy
• Schizophrenia
• Febrile Convulsions
• Anxiety Disorders
• Depressive Disorder
• Nervous System Disorder
• Bipolar Disorder

• Dysequilibrium Syndrome
• Mood Disorders
• Idiopathic Generalized Epilepsy
• Neurodegenerative Disorders
• Nerve Degeneration
• Convulsion Neonatal

Pathways

• Pathogenesis
• Synaptic Transmission
• Localization
• Reflex
• Righting Reflex
• Translation
• Methylation
• Cell Death
• Synapse Maturation
• Brain Development
• Cell Proliferation
• Signal Transmission
• Response To Hypoxia

• Dna Methylation
• Glycosylation
• Startle Response
• Drug Resistance
• Locomotion
• Innervation
• Cell Adhesion

PTMs

• Phosphorylation

• Methylation

• Biotinylation

Research Areas

• Neuronal Cell Markers
• Neuroscience
• Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GABRA1

Best Uses of the Boster Bio Anti-GABA A Receptor Alpha 1 Marker

This article will help you learn the best ways to use the Boster Bio Anti-GABA A Receptor Alpha 1/GABRA1 Marker. Find out more about this biomarker's specific applications, as well its product range or custom services. You'll be glad that you did. Contact us for more information.

Boster Bio Anti-GABA A Receptor alpha 1/GABRA1 Marker

GABA A Receptor alpha 1 a membrane-associated 456 amino acid protein that belonged to the Gamma aminobutyric Acid receptor subfamily. This antibody reacts with both the human and mouse GABAA receptors. GABA receptors are crucial in neurotransmitter communication. The function of these receptors, however, is not well understood.

The protein encodes an important role in context-dependent action selection. It functions as a receptor for histamine and mediates cell responses to it. This protein is identified by a marker. This product can be used to help researchers identify a certain protein. The protein regulates context dependent actions in neurons or glial tissues.

Specific applications

The GABRA1 gene is upregulated during the first postnatal years of human development, and contributes to several subtypes of GABAA receptors, including synaptic (a1bxg2 receptors), extrasynaptic (a1bxd receptors), and intercellular (a1bxc receptors). These GABAA receivers are part of the Cys loop receptor superfamily. Each subunit of a receptor is made up of three domains, the extracellular domain and the topological domain.

GABAA receptor genes are susceptible to genetic variants. Many of these variants do not cause phenotypes and are therefore nonpathogenic. However, some are pathogenic and may increase your risk for developing neurodevelopmental syndromes and idiopathic globalized epilepsy. This new marker could be used to help scientists identify epilepsy patients and other people suffering from disorders involving GABAA receptor subunits.

GABRA1 is also associated with hereditary generalized epilepsies such as juvenile myoclonic seizures. This variant has also been linked to sporadic epilepsies such as Ohtahara and Dravet syndromes. These findings suggest that this gene plays an important role in the development the nervous system. The genetic marker can also be used to aid in the investigation of the causes of various diseases.

In mice, GABRA1 expression induces a marked increase in dendritic spines in cortical pyramidal cells. Using confocal imaging, the effects of GFP and CRE knockdown on spine density are demonstrated. The high-magnification images show the axons' mushroom spines with yellow arrowheads indicating those that are thin and insufficiently developed.

Product range

The GABRA1 mark is an important protein that regulates contextdependent action selection. It functions as a histamine receptor, and mediates cellular reactions. GABRA1 shows features of a transmembrane or topological domain. Its role in colorectal carcinoma is not known. There are many products that can detect the marker. Here is a breakdown of the range of GABRA1 markers.

All statistical analyses were performed with IBM SPSS software. The significance level for all analyses was 0.05. Outliers were defined at values greater than 2 standard deviations from the average and were excluded for further analysis. Shapiro-Wilk tests were used to verify normality and homogeneity in variance for both protein and genome expression data. The Levene test failed to pass PV, GABRA1, SST and PV, indicating that their levels were not normally distributed.