This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Forkhead box protein O4.
Down-regulates expression of HIF1A and inhibits hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.
Human | |
---|---|
Gene Name: | FOXO4 |
Uniprot: | P98177 |
Entrez: | 4303 |
Belongs to: |
---|
No superfamily |
AFX; AFX1myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog);translocated to, 7; Fork head domain transcription factor AFX1; forkhead box O4; forkhead box protein O4; MLLT7MGC120490; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);translocated to, 7
Mass (kDA):
53.684 kDA
Human | |
---|---|
Location: | Xq13.1 |
Sequence: | X; NC_000023.11 (71095851..71103534) |
Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.
Cytoplasm. Nucleus. When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.
PMID: 9341872 by Peters U., et al. AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as candidate genes of X-linked dystonia parkinsonism.
PMID: 9010221 by Borkhardt A., et al. Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13;q23).