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FLT4 Antibodies
AND FLT4 ELISA kits, FLT4 Proteins
Many biological assays use antibodies to detect FLT4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FLT4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FLT4 antibodies...
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FLT4 Infographic by Boster Bio
All FLT4 Products
Product
Figures
Specificity
Applications
Price
Mouse VEGFR3/FLT4 ELISA Kit PicoKine®
1 Citations 7 Q&As
Mouse
ELISA
$499
Cat # EK0546
96 wells/kit, with removable strips.
Cat # EK0546
96 wells/kit, with removable strips.
Rat VEGFR3/FLT4 ELISA Kit PicoKine®
1 Citations 7 Q&As
Rat
ELISA
$499
Cat # EK1347
96 wells/kit, with removable strips.
Cat # EK1347
96 wells/kit, with removable strips.
Anti-VEGF Receptor 3/FLT4 Antibody Picoband®
2 Citations
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # A01276-2
100 μg/vial
Cat # A01276-2
100 μg/vial
Anti-VEGF Receptor 3/FLT4 Antibody Picoband®
4 Citations 3 Q&As
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # A01276-3
100 μg/vial
Cat # A01276-3
100 μg/vial
Human
$250
Cat # PROTP35916
2ug, 10ug, 1mg
Cat # PROTP35916
2ug, 10ug, 1mg
Human
ELISA
$499
Cat # EK0545
96 wells/kit, with removable strips.
Cat # EK0545
96 wells/kit, with removable strips.
FLT4 Overview
Facts about Vascular endothelial growth factor receptor 3.
Vascular endothelial growth factor receptor 3 (FLT4)
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, migration and survival of endothelial cells, and regulates angiogenic sprouting.
Signaling by triggered FLT4 leads to improved production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. The secreted isoform 3 may be a decoy receptor for VEGFC and/or VEGFD and play an essential part as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | FLT4 |
| Uniprot: | P35916 |
| Entrez: | 2324 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.10; EC 2.7.10.1; FLT4; Flt-4; fms-related tyrosine kinase 4; LMPH1A; PCLFLT41; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; Tyrosine-protein kinase receptor FLT4; vascular endothelial growth factor receptor 3; VEGF R3; VEGFR3; VEGFR-3; VEGFR3Fms-like tyrosine kinase 4
Molecular Weight
Mass (kDA):
152.757 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q35.3 |
| Sequence: | 5; NC_000005.10 (180601506..180650298, complement) |
Tissue Specificity
Detected in endothelial cells (at protein level). Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Ligand-mediated autophosphorylation leads to rapid internalization.; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Ligand-mediated autophosphorylation leads to rapid internalization.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted. Cytoplasm.
Diseases
- Neoplasms
- Tumor Angiogenesis
- Lymphedema
- Milroy Disease
- Malignant Neoplasms
- Neoplasm Metastasis
- Pathologic Neovascularization
- Edema
- Leukemia
- Malignant Paraganglionic Neoplasm
- Lymphatic Metastasis
- Carcinoma
Interacting Proteins
- HSP90AB1
- KDR
- VEGFC
Pathways
- Angiogenesis
- Lymphangiogenesis
- Localization
- Pathogenesis
- Vasculogenesis
- Cell Proliferation
- Cell Growth
- Cell Migration
- Transport
- Endothelial Cell Proliferation
- Wound Healing
- Dna Methylation
- Methylation
PTMs
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FLT4
bosterbio.com/bosterbio-gene-info-cards/FLT4
References
PMID: 1327515 by Pajusola K., et al. FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.
PMID: 1319394 by Galland F., et al. Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene.
6 Publications of Boster FLT4 Antibodies & ELISA Kits
- PubMed ID: 10.3892/etm.2021.9986, Expression levels of VEGF‑C and VEGFR‑3 in renal cell carcinoma and their as...
- PubMed ID: 10.1016/j.arcmed.2007.06.021, Expression of Cyclooxygenase-2 and Vascular Endothelial Growth Factor-C Correlat...
- PubMed ID: 10.1007/s11670-010-0303-5, Interleukin-18 suppresses angiogenesis and lymphangiogenesis in implanted Lewis ...
- PubMed ID: -, Li,X.,Song,D.,Liu,H.,Wang,Z.,Ma,G.,Yu,M. ... Zeng,Y.(2021).Expression levels of ...
- PubMed ID: 16961284 , Serum vascular endothelial growth factor-C and vascular endothelial growth facto...
- PubMed ID: 24040410, Li C, Fan J, Song X, Zhang B, Chen Y, Li C, Mi K, Ma H, Song Y, Tao X, Li G. Plo...
*More publications can be found for each product on its corresponding product page