FGF7 Antibodies

Fibroblast growth factor 7 (FGF7)

Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis.

Growth factor active on keratinocytes. Possible important paracrine effector of normal epithelial cell proliferation.

Gene Information

Human
Gene Name:	FGF7
Uniprot:	P21781
Entrez:	2252

Family

Belongs to:
heparin-binding growth factors family

Alternative Names

FGF7; FGF-7; fibroblast growth factor 7HBGF-7; HBGF7; HBGF-7; Heparin-binding growth factor 7; keratinocyte growth factor; KGF; KGFfibroblast growth factor 7 (keratinocyte growth factor)

Molecular Weight

Mass (kDA):
22.509 kDA

Genomic Context

Human
Location:	15q21.2
Sequence:	15; NC_000015.10 (49423242..49488775)

Tissue Specificity

Epithelial cell.

Subcellular Localizations

Secreted.

Diseases

• Malignant Neoplasms
• Neoplasms
• Hyperplasia
• Carcinoma
• Lung Injury
• Inflammation
• Prostatic Neoplasms
• Fibrosis
• Mucositis
• Cell Transformation, Neoplastic
• Mammary Neoplasms
• Prostatic Hyperplasia

• Malignant Neoplasm Of Prostate
• Stomatitis
• Benign Prostatic Hypertrophy
• Tumor Angiogenesis
• Malignant Paraganglionic Neoplasm
• Ulcer

Pathways

• Cell Proliferation
• Wound Healing
• Cell Growth
• Secretion
• Regeneration
• Epithelial Cell Proliferation
• Cell Differentiation
• Localization
• Pathogenesis
• Angiogenesis
• Transport
• Keratinocyte Proliferation
• Lung Development

• Cell Cycle
• Cell Migration
• Lung Morphogenesis
• Cell Death
• Epithelial Cell Differentiation
• Gland Development
• Keratinocyte Differentiation

PTMs

• Phosphorylation
• Cleavage
• Methylation
• Biotinylation
• Oxidation
• Sulphation

• Nitration
• Glycosylation
• Deacetylation
• Acetylation
• Dephosphorylation
• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FGF7

Boster Bio - Best Uses Of The FGF7 Marker

In this article, we will discuss the most important features of the Boster Bio: Stability, Applications, and Applications. The Boster Bio is the most popular Anti-KGF/FGF7 marker on the market today. Read on for more details! This article is not a substitute for professional medical advice. It is only meant to provide a general understanding of the FGF7 protein and its applications.

Boster Bio

The Boster Bio Anti-Fibroblast Growth Factor 8 (FGF7) Antibody is a highly specific reagent for detection of FGF7 protein. It reacts with Human, Mouse, and Rat. The antibody was developed by Steven Boster. In 1993, he developed the first product, earning the nickname "he who converts science in the lavatory." The company has since grown to become the largest catalog antibody manufacturer in China.

Anti-KGF/FGF7 Marker

The Anti-KGF/FGF7 Markers in Boster Bio are intended to detect circulating KGF/FGF7 in the plasma of patients with pulmonary disease. These antibodies recognize the mRNA and protein expression of surfactant proteins. They can also detect changes in cellular and molecular function. The specific alterations in biochemical properties of these proteins are unknown.

In this study, the anti-KGF/FGF7 marker was used to detect changes in the expression of LC3-II. It inhibited autophagosome formation by selectively blocking fusion of the lysosome. It did not affect the expression of the SQSTM1 protein. In addition, TG inhibits the degradation of LC3-II.

The quantitative fluorescence analysis showed that three-MA reduced the number of EGFP-LC3-positive dots in cultured cells. Moreover, 3-MA decreased the percentage of KRT1-positive cells. These results were obtained using methods described in Materials and Methods. Results are expressed as mean values plus standard errors. If you are interested in purchasing a Boster Bio Anti-KGF/FGF7 Marker, please check the supplemental information below.

KGF instillation increases the expression of surfactant protein mRNA. SP-A and SP-D mRNA levels are significantly elevated after KGF treatment. CC10 mRNA is also increased in lung cells after KGF instillation. All these results support the hypothesis that KGF induces the production of surfactant proteins. Furthermore, despite the alterations, the expression levels of CC10 and CC11 in type II cells are reduced.

In addition to regulating the turnover of autophagosomes, FGF7 also plays a role in epithelial cell differentiation. It also speeds up the turnover of autophagosomes. Furthermore, it is associated with the fusion of autophagosomes with lysosomes. The role of FGF7 in epithelial cells cannot be ignored.

Stability

The FGF7 marker was previously referred to as KGF and was reclassified as FGF7 in 1989. Previously, KGF was a non-coding RNA and had been implicated in tumor growth. Its role in tumor growth is well understood, as it has been implicated in the proliferation of epithelial cells in the gastrointestinal tract. In addition, it has been implicated in several epithelial cell lines, including goblet cells.

Moreover, FGF7 promotes the proliferation of basal keratinocytes. Furthermore, this molecule replaces EGF in KCM, which improves hiPSC-bK differentiation. However, the recombinant FGF7 shows enhanced survival and morphology in hiPSC-bKs. The researchers also showed that FGF7 promotes the generation of apoptosis-derived keratinocytes.

Applications

The FGF7 marker is a genetic marker that has numerous applications. It can be used to assess the performance of a person or animal. It inhibits the formation of primary pelage and whisker HF in mice. The Wnt signaling pathway is prominent during E14.5-15.5, the time of formation of the HF placodes. Its robust downregulation could enhance HF formation. This marker can also be used in genetic modification.

This biomarker is expressed ubiquitously in different cell lines, including the DPCs, sFBs, and KCs. The FGF7 gene is essential in tissue repair and is widely expressed in these three lineages. In addition, it is highly expressed in squamous epithelial cells. It is expressed by all three subgroups of dermal cells. The FGF7 gene is also expressed in neurons in the brain, and in fibroblasts in the bone marrow.

In vivo expression of the FGF7 marker in human fibroblasts has been related to the normal situation of tumour development in animals. It is expressed on keratinocytes, which surround tumour cells in animal models. Moreover, the FGF7 marker is produced by CUSABIO's strict quality control regime, and its reagents are backed by solid technical support. If you are planning to purchase this marker for research purposes, be sure to read the supplementary information.

The FGF7 gene is encoded by four structurally related genes, and they encode the fibroblast growth factor receptors. The genes encoding the receptors produce further isoforms. Fgfr2b and Fgfr2c are epithelial and mesenchymal, respectively. The FGF7 gene is essential for growth in tissues and organs. If the receptor is expressed in the correct cells, it can be used as a stratifying marker.

History

The history of the FGF7 marker began with the discovery that the fibroblast growth factor (FGF) 7 receptor inhibited keratinocyte differentiation. Terauchi et al. subsequently demonstrated that FGF7 acts as a target-derived presynaptic organizer in the mammalian brain. This discovery has been followed by other research to identify other functions of the FGF7 receptor.

The FGF-7-expressing cells produced an increased cell number in the epidermis. These cells were also more densely packed. This process increased cell number. The epidermis grew thicker and was more densely packed. In the skin, the expression of FGF-7 in the epidermis is an indication that the receptor is involved in cell proliferation and differentiation. These effects were also evident in the formation of the epidermal barrier.

FN38 inhibits FGFR2b, which increases autophagy. In addition, the b1-integrin signal is reduced. This suggests that FGFR2b is internalized and may undergo degradation. FGFR2b also induces changes in autophagic and early differentiation genes. The changes in expression signatures resemble those observed in skin equivalents. FN38 and FGFR2b expression in skin cells were confirmed by biochemical, immunofluorescence, and molecular approaches.

In addition to its role in wound healing, FGF-7 is a crucial molecule in innate immune responses. It is produced by keratinocytes and activates the production of IL-1 and IL-6 by promoting their activity. The FN35LR receptor is also involved in the innate immune response. Its expression promotes the wound healing process. Moreover, it is important for the immune system to produce FN35, a crucial hormone in the skin.