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- Table of Contents
Facts about Fc receptor-like A.
Human | |
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Gene Name: | FCRLA |
Uniprot: | Q7L513 |
Entrez: | 84824 |
Belongs to: |
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No superfamily |
Fc receptor homolog expressed in B cells (FREB); Fc receptor homolog expressed in B-cells; Fc receptor related protein X; Fc receptor-like A; Fc receptor-like and mucin-like 1; Fc receptor-related protein X; FCRL1; FCRLA; FCRLb; FCRLc1; FCRLc2; FCRLd; FCRLe; FCRLFc receptor-like protein; FCRLM1; FCRLX; FcRX; FREB; FREBFc receptor-like and mucin-like protein 1; MGC4595
Mass (kDA):
38.927 kDA
Human | |
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Location: | 1q23.3 |
Sequence: | 1; NC_000001.11 (161707022..161714352) |
Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes.
Cytoplasm. Seems not to be secreted.
Although the FCRLA markers have many promising uses, their best uses are still unknown. This article will highlight some of the most recent research conducted at different institutes. Ctr Hlth Aging and Univ Oslo and Synapt Neurchem Lab are examples of these institutions. Boster Bio: Best uses of the FCRLA marker provides more information on the FCRLA genetic gene.
The Neurochem lab at Univ Oslo published results using the fluorescent marker. These results confirm previous research that identified FCRLA as a key component of neurotransmitter NMDA. It was discovered by Professors M. C. Alves, Galeano D. C. Fisone G. and Santos W. S.
PMID: 11754007 by Mechetina L.V., et al. FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features.
PMID: 11891275 by Facchetti F., et al. An unusual Fc receptor-related protein expressed in human centroblasts.