This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
FASLG Antibodies
AND FASLG ELISA kits, FASLG Proteins
Many biological assays use antibodies to detect FASLG, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FASLG in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FASLG antibodies...
Previous: A1BG
Next: ABCC6
FASLG Infographic by Boster Bio
All FASLG Products
Product
Figures
Specificity
Applications
Price
Human FASL / CD95LG / CD95 Ligand ELISA Kit PicoKine®
6 Citations 6 Q&As
Human
ELISA
$499
Cat # EK0337
96 wells/kit, with removable strips.
Cat # EK0337
96 wells/kit, with removable strips.
Mouse FASL ELISA Kit PicoKine®
10 Citations 6 Q&As
Mouse
ELISA
$499
Cat # EK0338
96 wells/kit, with removable strips.
Cat # EK0338
96 wells/kit, with removable strips.
Rat FASL ELISA Kit PicoKine®
2 Citations 7 Q&As
Rat
ELISA
$499
Cat # EK1110
96 wells/kit, with removable strips.
Cat # EK1110
96 wells/kit, with removable strips.
Human
ELISA
$499
Cat # FEK0337
96 wells/kit, with removable strips.
Cat # FEK0337
96 wells/kit, with removable strips.
Human
Flow Cytometry, IP, ICC, WB
$291
Cat # M00925-2
0.1 mg
Cat # M00925-2
0.1 mg
FASLG Overview
Facts about Tumor necrosis factor ligand superfamily member 6.
Tumor necrosis factor ligand superfamily member 6 (FASLG)
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603).
Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | FASLG |
| Uniprot: | P48023 |
| Entrez: | 356 |
Family
| Belongs to: |
|---|
| tumor necrosis factor family |
Alternative Names
apoptosis (APO-1) antigen ligand 1; Apoptosis antigen ligand; APT1LG1CD95L; APTL; CD178 antigen; CD178; CD95L; CD95-L; Fas antigen ligand; Fas ligand (TNF superfamily, member 6); Fas Ligand; FASLCD95 ligand; FASLG; TNFSF6; TNFSF6FasL; tumor necrosis factor (ligand) superfamily, member 6; tumor necrosis factor ligand superfamily member 6
Molecular Weight
Mass (kDA):
31.485 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q24.3 |
| Sequence: | 1; NC_000001.11 (172659008..172666876) |
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen. Lysosome lumen. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290). Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115).; [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted. May be released into the extracellular fluid by cleavage from the cell surface.; [FasL intracellular domain]: Nucleus. The FasL ICD cytoplasmic form is translocated into the nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Autoimmune Reaction
- Malignant Paraganglionic Neoplasm
- Inflammation
- Leukemia
- Autoimmune Diseases
- Adenocarcinoma
- Lymphoma
- Hiv Infections
- Hepatitis
- Neoplasm Metastasis
Interacting Proteins
- Ap2b1
- CASP8
- FADD
- FAS
- FNBP1
- FYN
- ITK
- KRT40
- NCK2
- NOTCH2NL
Pathways
- Cell Death
- Pathogenesis
- Induction Of Apoptosis
- Immune Response
- Programmed Cell Death
- Cell Proliferation
- Cell Cycle
- Secretion
- Cell Growth
- Cell Activation
- Localization
- Sensitization
- Inflammatory Response
PTMs
- Cleavage
- Phosphorylation
- Dephosphorylation
- Reduction
- Acetylation
- Methylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FASLG
bosterbio.com/bosterbio-gene-info-cards/FASLG
Best Uses Of The FASLG Marker
The FASLG marker is a distinctive monoclonal antibody, which has many applications in medicine and biology. It has been used to detect the process of apoptosis. This monoclonal antibody is also capable of detecting the anti-Bax protein, which is a specific marker that detects the apoptosis process. The FASLG marker is applicable to all scientists in the world as well as scientists working on species and their applications.
Anti-Bax (Apoptosis Marker) Monoclonal Antibody
This monoclonal antibody recognizes Bax (Apoptosis Marker) which is a transcription factor that is linked to apoptosis. Antibodies to this protein could stop the process of apoptosis. These antibodies are made by various companies. Boster Bio, the company that developed the antibody has a variety of types available.
Boster Bio's monoclonal anti-Bax (Apoptosus Marker), reacts to human Bax. It has been tested in a variety of tests and has multiple applications in different research labs. Multiple assays have been used to validate the antibodies. These results are crucial in diagnosing apoptosis.
In a research study using the monoclonal antibody, the N27-2 clone was transfected by mutant hPRA1, the BHRF1, and p-Bax. The OE group had a higher rate of apoptosis than the other two groups. Western blot tests were performed to measure the expression of proteins. Anti-Bax decreased Bcl-2, cleaved-PARP, and caspase-3 expression in OE cells. The pro-apoptotic protein PCNA was not affected.
The active immunization with this antibody boosted the apoptotic marker, CC3, in tumors, but passive immunization did not increase CC3 or Ki67 in tumor cells. The results suggest that both immunotherapy options have an antitumor affect. The immune response is activated when apoptotic cells are triggered by the antibody.
References
PMID: 7528780 by Alderson M.; Fas ligand mediates activation-induced cell death in human T lymphocytes.
PMID: 7826947 by Takahashi T., et al. Human Fas ligand: gene structure, chromosomal location and species specificity.
17 Publications of Boster FASLG Antibodies & ELISA Kits
- PubMed ID: 10.4049/jimmunol.1602175, The Upregulation of Integrin αDβ2 (CD11d/CD18) on Inflammatory Macrophages Pro...
- PubMed ID: 10.3390/ijms20040920, Potential Analysis and Preparation of Chitosan Oligosaccharides as Oral Nutritio...
- PubMed ID: 10.1155/2018/4310419, Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and...
- PubMed ID: 10.1080/0886022X.2018.1456938, Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding
- PubMed ID: 10.1002/stem.2210, Molecular and Cellular Functions Distinguish Superior Therapeutic Efficiency of ...
- PubMed ID: -, Lanfen Chen,Wei Chen,Mengbei Zhang et al.Comparison of therapeutic effects of me...
- PubMed ID: -, Yan Zhang,Linchao Zhang,JiaLu Bao et al.Perfluorooctanoic Acid Exposure in Early...
- PubMed ID: 33513976, Ferguson Bennit HR,Gonda A,Kabagwira J,Oppegard L,Chi D,Licero Campbell J,De Leo...
- PubMed ID: 30524196 , Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and...
- PubMed ID: 29619879, Cisplatin-induced oxidative stress stimulates renal Fas ligand shedding
- PubMed ID: 28500072, The upregulation of integrin ?D?2 (CD11d/CD18) on inflammatory macrophages promo...
- PubMed ID: 20222173, Li Q, Peng J, Li Xh, Liu T, Liang Qc, Zhang Gy. World J Gastroenterol. 2010 Mar ...
- PubMed ID: 19244542, Han X, Qiu L, Zhang Y, Kong Q, Wang H, Wang H, Li H, Duan C, Wang Y, Song Y, Wan...
- PubMed ID: 21159039, Xu J, Liu H, Wu Y, Gong X, Zhou Q, Qiao F. J Obstet Gynaecol Res. 2011 Mar;37(3)...
- PubMed ID: 20117771, Xiong M, Lu J, Zhao A, Xu L, Bao S, Lin Q, Yang B. Fertil Steril. 2010 May 15;93...
- PubMed ID: 24604244, Jiang H, Li J, Zhou T, Wang C, Zhang H, Wang H. Int J Mol Med. 2014 May;33(5):12...
- PubMed ID: 24714963, Wu Yh, Hu Sq, Liu J, Cao Hc, Xu W, Li Yj, Li Lj. Int J Mol Med. 2014 Jun;33(6):1...
*More publications can be found for each product on its corresponding product page