Hyccin Antibodies

AND Fam126a ELISA kits, Hyccin Proteins

Many biological assays use antibodies to detect Hyccin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Hyccin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Hyccin antibodies...

We validate the specificity of these antibodies to Hyccin by testing them on tissues known to express Fam126a positively and negatively. Browse below to find the Fam126a antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Fam126a Infographic by Boster Bio

All Fam126a Products

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Specificity

Applications

Price

FAM126A (NM_032581) Human Over-expression Lysate

Human

$628
Cat # LS084668
100 µg

Fam126a Overview

Facts about Hyccin.

Hyccin (Fam126a)

Component of a complex needed to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex functions as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis.

FAM126A plays an integral role in oligodendrocytes formation, a cell type with expanded plasma membrane which requires generation of PtdIns(4)P. Its role in oligodendrocytes formation likely explains its significance in myelination of the central and peripheral nervous system.

Gene Information

Mouse
Gene Name:	Fam126a
Uniprot:	Q6P9N1
Entrez:	84652

Family

Belongs to:

FAM126 family

Alternative Names

Down-regulated by CTNNB1 protein A; DRCTNNB1Aa; family with sequence similarity 126, member A; HLD5; hyccin; Protein FAM126A

Molecular Weight

Mass (kDA):
57.321 kDA

Genomic Context


Mouse

Location:	5\|5 A3
Sequence:	5;

Tissue Specificity

Predominantly expressed in the central nervous system, where it is found in neurons but not in myelinating cells. Lower abundance is observed in peripheral neurons, where it is detectable only at early postnatal ages (PubMed:22461884). Expressed in both oligodendrocytes and neurons (PubMed:26571211).

Diseases

Cataract
Nervousness
Pelizaeus-merzbacher Disease
Leukoencephalopathies
Developmental Delay (disorder)
Peripheral Neuropathy
Demyelinating Diseases
Mitochondrial Diseases
Colonic Neoplasms
Ataxia

Malignant Tumor Of Colon
Carcinoma
Carcinogenesis
Malignant Neoplasms
Neoplasms

Pathways

Myelination

PTMs

Phosphoprotein

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Fam126a

References

PMID: 10910037 by Kawasoe T., et al. Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin.

PMID: 22461884 by Gazzerro E., et al. Hyccin, the Molecule Mutated in the Leukodystrophy Hypomyelination and Congenital Cataract (HCC), Is a Neuronal Protein.