This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Hyccin.
FAM126A plays an integral role in oligodendrocytes formation, a cell type with expanded plasma membrane which requires generation of PtdIns(4)P. Its role in oligodendrocytes formation likely explains its significance in myelination of the central and peripheral nervous system.
Mouse | |
---|---|
Gene Name: | Fam126a |
Uniprot: | Q6P9N1 |
Entrez: | 84652 |
Belongs to: |
---|
FAM126 family |
Down-regulated by CTNNB1 protein A; DRCTNNB1Aa; family with sequence similarity 126, member A; HLD5; hyccin; Protein FAM126A
Mass (kDA):
57.321 kDA
Mouse | |
---|---|
Location: | 5|5 A3 |
Sequence: | 5; |
Predominantly expressed in the central nervous system, where it is found in neurons but not in myelinating cells. Lower abundance is observed in peripheral neurons, where it is detectable only at early postnatal ages (PubMed:22461884). Expressed in both oligodendrocytes and neurons (PubMed:26571211).
PMID: 10910037 by Kawasoe T., et al. Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin.
PMID: 22461884 by Gazzerro E., et al. Hyccin, the Molecule Mutated in the Leukodystrophy Hypomyelination and Congenital Cataract (HCC), Is a Neuronal Protein.