FYN-binding protein 1 Antibodies

FYN-binding protein 1 (FYB1)

Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells.

Modulates the expression of interleukin-2 (IL-2).

Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.

Gene Information

Human
Gene Name:	FYB1
Uniprot:	O15117
Entrez:	2533

Family

Belongs to:
No superfamily

Alternative Names

ADAP; Adhesion and degranulation promoting adaptor protein; adhesion and degranulation-promoting adaptor protein; FYB; FYB-120/130SLAP-130FYN-binding protein (FYB-120/130); FYN binding protein; FYN-binding protein; FYN-T-binding protein; p120/p130; PRO0823; SLAP130; SLP-76-associated phosphoprotein

Molecular Weight

Mass (kDA):
85.387 kDA

Genomic Context

Human
Location:	5p13.1
Sequence:	5; NC_000005.10 (39105252..39274500, complement)

Tissue Specificity

Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.

Subcellular Localizations

Cytoplasm. Nucleus. Cell junction. Colocalizes with TMEM47 at cell-cell contacts in podocytes.

Diseases

• Tissue Adhesions
• Malaria
• Hemolytic Disorder
• Erythroblastosis, Fetal
• Cell Invasion
• Yersinia Infections
• Blood Group Incompatibility
• Anemia
• Inflammation
• Malaria, Vivax
• Hemorrhage
• Hemolysis (disorder)
• Transfusion Reaction

• Anemia, Hemolytic
• Wiskott-aldrich Syndrome
• Chimera Disorder
• Cholangiocarcinoma
• Yersinia Pseudotuberculosis Infections
• Malignant Neoplasms
• Neoplasms

Interacting Proteins

• FYN
• LCP2
• NCK1
• NCK2
• SKAP1

Pathways

• Cell Activation
• T Cell Activation
• Cell Adhesion
• Integrin Activation
• Cytokine Production
• Cell Proliferation
• Localization
• Virulence
• Secretion
• Phagocytosis
• T Cell Proliferation
• Cell Migration
• Platelet Activation

• Pathogenesis
• Immune Response
• Lipid Binding
• T Cell Migration
• T Cell Cytokine Production
• Lymphocyte Activation
• Proteolysis

PTMs

• Phosphorylation
• Dephosphorylation
• Oxidation

• Cleavage
• Acylation
• Deglycosylation

• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FYB1

Best Uses Of The FYB1 Marker

This article will examine Boster Bio’s anti-FYB anti-Bacterial and the methods to detect it. It will also discuss the reliability, trustworthiness, and dependability of primary antibodies made in Boster Bio. The articles below will help you learn more.

Boster Bio's anti FYB antibody

Boster Biological Technology Anti-FYB FYB1 Antibody reacts to Human. It has been validated for WB and IHC as well as flow cytometry. The Antibody can be used on human tissue and can be stored at -20°C for up to one-year. To ensure quality, Boster Bio validates its antibodies on known positive and negative samples.

Methods of detection

Methods of detection of the FYB1 gene signature in Boster Bio are described in various publications. These studies have demonstrated the importance this gene signature has for identifying MSI or MSS cells. A number of publications have provided methods to detect the FYB1 gene signature, including those from Ronaghi et al., Shendure et al., and Imelfort et al., published in Brief Bioinform. 2009, 10(6):617-18, and Fox et al., Methods Mol. Biol. 553:79-108. Morozova et. al. published the same in Genomics. 2008, 92:255-64

Trust in Boster primary antibodies

A Boster antibody is of high quality and proven clinically effective. Boster antibodies are made in FDA-registered laboratories. All of its antibodies are also sourced from licensed suppliers. DARPin, for example, has a proven track record of supplying bioactive, high-quality antibodies. Boster primary antibody can provide quick turnaround if you have urgent needs.

Boster primary anti-bodies are reliable

Reliability of Boster prima antibodies depends on the method used to analyze antibody titres. There are several methods to determine whether a booster dose is immunogenic. It can be determined depending on the method used by calculating the GMT or neutralizing antibody levels against a reference strain. The following table summarizes the reliability of Boster primary antibodies.

The following criteria are used to assess the immunobiological reliability for a booster dose: A positive response rate against the reference strain, at least four-fold titer, a change of neutralizing antibody titre compared with baseline after Dose 1 and a 50% decrease in titers at most four times the pre-booster level. Postvaccination titer can also be considered a seroresponse.

Cost of Boster primary antibodies

If you're looking to get the best possible primary antibody for your research project, you should consider using Boster Biologicals' products. Their products have been in use for over 25 year as research tools. Their primary antibodies have been validated for use in Western Blotting, immunohistochemistry, and ELISA. Because of their unique characteristics, they have gained the trust and respect of the scientific community. And, at a reasonable price.

Boster Bio has over 16,000 valid antibodies that you can use in your research projects. They offer a wide range of products that include WB, IHC and ELISA as well as FC. They offer secondary antibodies at no additional cost with every primary antibody purchased. They are also manufactured with the highest quality standards. Their antibodies will retain their biological activities and work as promised.