FUT8 Antibodies

Alpha-(1,6)-fucosyltransferase (FUT8)

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, beside the peptide chains in N-glycans. .

Gene Information

Human
Gene Name:	FUT8
Uniprot:	Q9BYC5
Entrez:	2530

Family

Belongs to:
glycosyltransferase 23 family

Alternative Names

alpha 1,6 Fucosyltransferase; alpha-(1,6)-fucosyltransferase; alpha1-6FucT; EC 2.4.1.68; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); Fucosyltransferase 8; FUT8; GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465

Molecular Weight

Mass (kDA):
66.516 kDA

Genomic Context

Human
Location:	14q23.3
Sequence:	14; NC_000014.9 (65410592..65744122)

Subcellular Localizations

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Membrane-bound form in trans cisternae of Golgi.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Growth Retardation
• Tissue Adhesions
• Pulmonary Emphysema
• Liver Carcinoma
• Neoplasm Metastasis
• Lung Diseases
• Lung Diseases, Obstructive
• Malignant Neoplasm Of Liver
• Chronic Obstructive Airway Disease
• Malignant Tumor Of Colon

• Neoplasm Invasiveness
• Pancreatic Acinar Cell Carcinoma
• Liver Neoplasms
• Malignant Neoplasm Of Lung
• Acinar Cell Carcinoma
• Multiple Myeloma
• Cell Invasion

Pathways

• Fucosylation
• Antibody-dependent Cellular Cytotoxicity
• Glycosylation
• Complement-dependent Cytotoxicity
• Localization
• Cell Growth
• Transport
• Cell Adhesion
• Cell Differentiation
• Cell-cell Adhesion
• Protein Folding
• Integrin Activation
• Pathogenesis

• Aging
• Lung Development
• Inflammatory Response
• Protein Glycosylation
• Flight
• Fermentation
• Translation

PTMs

• Phosphorylation
• Glycosylation

• Biotinylation
• Cleavage

• Amination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FUT8

Best Uses Of The FUT8 Marker

If you are curious about the best uses of Boster Bio's FUT8 Marker, then keep reading. This article will show you why this marker is such a good choice for protein purification. It also explains how to optimize its performance. This article also discusses Vector Laboratories and Boster’s high-affinity prima antibodies. For scientists, these products will be of great interest to you.

Boster Bio optimization tips

Boster Bio optimization advice is for beginners. The FUT8 markers is a popular protein used in sports. The FUT8 marker has numerous functions, and a few simple tips will help you optimize your experiments. Among these are:

Benefits of the FUT8 marker

The FUT8Marker has many advantages. This marker is used to predict the patient's response to radiotherapy. This marker is a core fuzolation of CD147. Other benefits of the FUT8 Marker are:

The FUT8Marker can help you identify the enzymes that transform sugar to fructose. Its structure is based on the fact that fucosylation is a quality control point of sequential glycosylation. Each organism has its specific FUT8 organisation. It is important to identify the FUT8. This marker can be used to find the exact gene coding for an enzyme.

Human tumours often show an increase in FUT8. It is associated in overall survival, with disease-free survival, as well as recurrence free survival. Its presence does include abnormal expression of itself. However, FUT8-mediated changes in glycoprotein central fucosylation are also useful diagnostic indicators. The FUT8 marker allows doctors to target specific types of cancer and also determine whether the tumour is abnormally expressed FUT8.

Vector Laboratories

Vector Laboratories created the FUT8 mark recently. This marker is a powerful tool for studying cellular responses to different environmental and dietary stimuli. The FUT8 marker is able to identify genes and regulators that regulate expression. Researchers performed regulator effects analysis to determine which genes were regulated by FUT8. This analysis revealed that there were small molecules and transcription factors that regulate gene expression.

The FUT8 marker was used to analyze gene expression in breast tumor cells. It has proven highly useful in the identification of invasive cells. QIAGEN IPA software identified targets glycoproteins of FUT8 using two cell lines. The top 10 molecular function categories were almost identical in both cell line, though the order was not. This suggests that FUT8 might play a significant role in regulating the expressions of these proteins.

The FUT8 marker is essential for maintaining core fucosylation of B7H3 at N-glycans. FUT8 is essential for cell stability and promotes tumor suppression. Researchers can target tumor cells by regulating this gene. Talk to a doctor to learn more about FUT8-targeted treatments.

Boster's high-affinity prima antibodies

Boster offers a wide variety of high-affinity primary antibodies that have been extensively validated and well-cited in the research community. These antibodies are optimized for use with ELISA/WB assays. Boster also provides polyclonal antibodies that are mouse or human. These antibodies work exactly as they are described on the labels. Boster Bio's website has more information.

High affinity antibodies are the most popular primary antibodies. These antibodies recognize proteins specifically and wash out any non-specific bound material. ELISA is a useful tool for measuring specific substances in crude preparations. Boster's primary antibodies with high affinity use the FUT8 mark. The FUT8 marker helps identify antigens binding to the FUT8 Protein.

Boster's high-affinity primary antigens are compatible with all other molecular markers. These antibodies are very specific, which increases the chance of detecting more proteins. In contrast, traditional chromogenic mIHC relies on the use of antibodies that were raised in different species. Secondary antibodies used with fluorescent antigens provide additional amplification for mIHC analysis.

Primary antibodies are immunoglobulins able to bind specifically to antigens. Their affinity and specificity are two factors that determine their quality. These refer to how well they bind to unintended antigens. Higher affinity indicates higher quality, but low specificity means inferior antibody. Primary antibodies are useful for detection, measurement, purification, as well as measurement. But they can also be used for other applications.