FUT2 Antibodies

AND FUT2 ELISA kits, FUT2 Proteins

Many biological assays use antibodies to detect FUT2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FUT2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FUT2 antibodies...

We validate the specificity of these antibodies to FUT2 by testing them on tissues known to express FUT2 positively and negatively. Browse below to find the FUT2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FUT2 Infographic by Boster Bio

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Anti-FUT2 Antibody

Human

ELISA, IHC

$380
Cat # A02679
100ul

FUT2 Overview

Facts about Galactoside 2-alpha-L-fucosyltransferase 2.

FUT2 3D structure. Source: alphafold

Galactoside 2-alpha-L-fucosyltransferase 2 (FUT2)

Mediates the transfer of fucose into the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The subsequent epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146).

Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an important substrate for the last step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235).

Gene Information

Human
Gene Name:	FUT2
Uniprot:	Q10981
Entrez:	2524

Family

Belongs to:

glycosyltransferase 11 family

Alternative Names

alpha (1,2) fucosyltransferase; Alpha(1,2)FT 2; alpha(1,2)FT2; B12QTL1; EC 2.4.1.69; fucosyltransferase 2 (secretor status included); Fucosyltransferase 2; FUT2; galactoside 2-alpha-L-fucosyltransferase 2; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; Se; Se2; SEC2; SEC2SE; Secretor blood group alpha-2-fucosyltransferase; Secretor factor; SEJ

Molecular Weight

Mass (kDA):
39.017 kDA

Genomic Context


Human

Location:	19q13.33
Sequence:	19; NC_000019.10 (48695971..48705951)

Tissue Specificity

Small intestine, colon and lung.

Subcellular Localizations

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Membrane-bound form in trans cisternae of Golgi.

Diseases

Malignant Neoplasms
Tissue Adhesions
Infective Disorder
Neoplasms
Gastroenteritis
Crohn Disease
Virus Diseases
Malignant Neoplasm Of Stomach
Malignant Tumor Of Colon
Feline Urological Syndrome
Helicobacter Infections

Communicable Diseases
Ulcer
Malignant Paraganglionic Neoplasm
Cystic Fibrosis
Stomach Neoplasms
Fibrosis

Pathways

Fucosylation
Glycosylation
Pathogenesis
Secretion
Cell Adhesion
Immune Response
Gene Conversion
Mating
Estrus
Insemination
Localization
Methylation
Angiogenesis

Transport
Gene Silencing
Fertilization
Brain Development
Tube Formation
Inflammatory Response
Protein Glycosylation

PTMs

Glycosylation
Phosphorylation

Amination
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FUT2

References

PMID: 7876235 by Kelly R.J., et al. Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype.

PMID: 9219535 by Koda Y., et al. Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2).