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Proto-oncogene c-Fos Antibodies
AND FOS ELISA kits, Proto-oncogene c-Fos Proteins
Many biological assays use antibodies to detect Proto-oncogene c-Fos, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Proto-oncogene c-Fos in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Proto-oncogene c-Fos antibodies...
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FOS Infographic by Boster Bio
All FOS Products
Product
Figures
Specificity
Applications
Price
Anti-c-Fos Rabbit Monoclonal Antibody
6 Citations 4 Q&As
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M00297
100 μl
Cat # M00297
100 μl
Anti-C-FOS Monoclonal Antibody
11 Citations 15 Q&As
Human, Mouse, Rat
IF, IHC, ICC, WB
$299
Cat # M00297-3
100ul
Cat # M00297-3
100ul
Anti-c-Fos Rabbit Monoclonal Antibody, Clone#RM374
2 Citations 16 Q&As
Human
IHC, WB
$431
Cat # M00297-5
100uL
Cat # M00297-5
100uL
Human, Mouse, Rat
ELISA
$480
Cat # EKC1220
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1220
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2033
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2033
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2588
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2588
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2592
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2592
1 kit, containing two 96-well plates and all necessary reagents
Anti-c-Fos/FOS Antibody Picoband®
4 Citations
Human
ELISA, Flow Cytometry, WB
$370
Cat # A00297-1
100 μg/vial
Cat # A00297-1
100 μg/vial
FOS Overview
Facts about Proto-oncogene c-Fos.
Proto-oncogene c-Fos (FOS)
Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to socialize with symmetrical DNA half websites.
On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical role in regulating the development of cells destined to form and maintain the skeleton.
Gene Information
| Human | |
|---|---|
| Gene Name: | FOS |
| Uniprot: | P01100 |
| Entrez: | 2353 |
Family
| Belongs to: |
|---|
| bZIP family |
Alternative Names
activator protein 1; AP-1; cellular oncogene c-fos; Cellular oncogene fos; cFos; c-Fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; FOS; G0/G1 switch regulatory protein 7; G0S7; proto-oncogene c-Fos; v-fos FBJ murine osteosarcoma viral oncogene homolog
Molecular Weight
Mass (kDA):
40.695 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q24.3 |
| Sequence: | 14; NC_000014.9 (75278828..75282230) |
Subcellular Localizations
Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.
Diseases
- Pain
- Neoplasms
- Malignant Neoplasms
- Disease Of Adrenal Medulla
- Nervousness
- Inflammation
- Cell Transformation, Neoplastic
- Stress, Psychological
- Physiological Stress
- Carcinoma
- Hyperalgesia
- Pituitary Diseases
Interacting Proteins
- APP
- ATF2
- ATF4
- ATF7
- CLU
- COPS4
- DDIT3
- JUN
- JUNB
- JUND
Pathways
- Secretion
- Cell Proliferation
- Localization
- Cell Cycle
- Cell Growth
- Reflex
- Sensitization
- Mating
- Cell Death
- Fermentation
- Innervation
- Pathogenesis
- Transport
PTMs
- Phosphorylation
- Cleavage
- Reduction
- Dephosphorylation
- Methylation
- Biotinylation
- Oxidation
- Acetylation
- Ubiquitination
- Phosphorothioation
Research Areas
- Apoptosis
- Cancer
- Cellular Markers
- Hypoxia
- Transcription Factors and Regulators
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FOS
bosterbio.com/bosterbio-gene-info-cards/FOS
References
PMID: 6574479 by van Straaten F., et al. Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos protein.
PMID: 1658710 by Roux P., et al. Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse bone marrow stromal cells.
28 Publications of Boster Proto-oncogene c-Fos Antibodies & ELISA Kits
- PubMed ID: 10.3969/j.issn.1673-5374.2012.23.001, Neurotoxicity of intrathecal injections of dexmedetomidine into the rat spinal d...
- PubMed ID: 10.3748/wjg.14.5008, Positional and expressive alteration of prohibitin during the induced differenti...
- PubMed ID: 10.3390/cancers11030306, NMDA Receptor Signaling Mediates cFos Expression via Top2β-Induced DSBs in Glio...
- PubMed ID: 10.3109/15569543.2013.867884, Neurotoxic effect of chronic heroin administration on the expression of c-Fos an...
- PubMed ID: 10.1080/1028602042000325609, Effects of isoliensinine on angiotensin II-induced proliferation of porcine coro...
- PubMed ID: 10.1038/srep27914, miR-144 and targets, c-fos and cyclooxygenase-2 (COX2), modulate synthesis of PG...
- PubMed ID: 10.1016/S1673-5374(07)60010-3, Protective effect of Angelica sinensis on cerebral neurons from rat embryos unde...
- PubMed ID: 10.1016/j.tiv.2016.12.016, Alterations in transcription and protein expressions of HCC-related genes in Hep...
- PubMed ID: 10.1016/j.pnpbp.2008.12.002, Effects of acute and chronic administration of MK-801 on c-Fos protein expressio...
- PubMed ID: 10.1016/j.joen.2007.07.034, Correlation between the Expression of c-Fos and Osteoclasts in Induced Periapica...
- PubMed ID: 10.1016/j.cbi.2017.07.020, Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite ...
- PubMed ID: 10.1007/s10565-008-9054-1, Genistein induces G 2 /M cell cycle arrest via stable activation of ERK1/2 pathw...
- PubMed ID: 12632510, Overexpression of c-fos in Helicobacter pylori-induced gastric precancerosis of ...
- PubMed ID: 30458282, Changes in the expression of c-fos & heat shock protein genes & blood fl...
- PubMed ID: 29541173, Tumor suppressive role of miR-569 in lung cancer
- PubMed ID: 18763282, Positional and expressive alteration of prohibitin during the induced differenti...
- PubMed ID: 27429635, Analgesic Neural Circuits Are Activated by Electroacupuncture at Two Sets of Acu...
- PubMed ID: 27297132, miR-144 and targets, c-fos and cyclooxygenase-2 (COX2), modulate synthesis of PG...
- PubMed ID: 26491460, The Expression Patterns of c-Fos and c-Jun Induced by Different Frequencies of E...
- PubMed ID: 25624799, Neurotoxicity of intrathecal injections of dexmedetomidine into the rat spinal d...
- PubMed ID: 24140441, Liu W, Peng Qx, Lin Xl, Luo Ch, Jiang Mj, Mo Zx, Yung Kk. Fitoterapia. 2014 Jan;...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page