fMet-Leu-Phe receptor Antibodies

AND FPR1 ELISA kits, fMet-Leu-Phe receptor Proteins

Many biological assays use antibodies to detect fMet-Leu-Phe receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with fMet-Leu-Phe receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop fMet-Leu-Phe receptor antibodies...

We validate the specificity of these antibodies to fMet-Leu-Phe receptor by testing them on tissues known to express FPR1 positively and negatively. Browse below to find the FPR1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FPR1 Infographic by Boster Bio

All FPR1 Products

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Anti-FPR1/Fpr Antibody

6 Q&As

Human, Mouse, Rat

ELISA, IF, IHC-P, ICC, WB

$335
Cat # A02509
100ul

Anti-FPR1 (I207) Antibody

Human, Mouse, Rat

$405
Cat # A02509-3
100ul

FPR1 Overview

Facts about fMet-Leu-Phe receptor.

FPR1 3D structure. Source: alphafold

fMet-Leu-Phe receptor (FPR1)

High affinity receptor for N-formyl-methionyl peptides (fMLP), which are strong neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520).

This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1712023, PubMed:10514456). .

Gene Information

Human
Gene Name:	FPR1
Uniprot:	P21462
Entrez:	2357

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

fMet-Leu-Phe receptor; fMLF-R; fMLP receptor; FMLP; formyl peptide receptor 1; FPR1; FPRfMet-Leu-Phe receptor; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor

Molecular Weight

Mass (kDA):
38.446 kDA

Genomic Context


Human

Location:	19q13.41
Sequence:	19; NC_000019.10 (51745172..51751878, complement)

Tissue Specificity

Neutrophils.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Internalizes in presence of its ligand, TAFA4.

Diseases

Inflammation
Inflammatory Response
Neoplasms
Infective Disorder
Alzheimer's Disease
Periodontitis
Malignant Neoplasms
Cell Invasion
Periodontitis, Juvenile
Pertussis
Arthritis
Tissue Adhesions
Bacterial Infections

Tissue Damage
Neurodegenerative Disorders
Innate Immune Response
Ulcer
Rheumatoid Arthritis
Malignant Paraganglionic Neoplasm
Cardiovascular Diseases

Interacting Proteins

GRK2
MAPK13

Pathways

Chemotaxis
Mating
Fertilization
Localization
Inflammatory Response
Cell Migration
Neutrophil Chemotaxis
Cell Cycle
Secretion
Immune Response
Cell Activation
Neutrophil Activation
Virulence

Wound Healing
Leukocyte Chemotaxis
Protein Folding
Pathogenesis
Leukocyte Migration
Reverse Transcription
Phagocytosis

PTMs

Phosphorylation
Formylation
Cleavage

Reduction
Glycosylation
Oxidation

Research Areas

GPCR
Immunology
Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FPR1

References

PMID: 2161213 by Boulay F., et al. Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA.

PMID: 2176894 by Boulay F., et al. The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors.