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- Table of Contents
Facts about Fibronectin type III domain-containing protein 4.
Affects key macrophage functions, including phagocytosis, by downregulating many important pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.
Mouse | |
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Gene Name: | Fndc4 |
Uniprot: | Q3TR08 |
Entrez: | 64339 |
Belongs to: |
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No superfamily |
fibronectin type III domain containing 4; fibronectin type III domain-containing protein 4; Fibronectin type III repeat-containing protein 1; FNDC4; FRCP1; FRCP1FLJ22362
Mass (kDA):
24.933 kDA
Mouse | |
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Location: | 5|5 B1 |
Sequence: | 5; |
Highly expressed in adult liver and brain tissues.
PMID: 12384288 by Teufel A., et al. Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes.
PMID: 27066907 by Bosma M., et al. FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice.