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- Table of Contents
Facts about Dimethylaniline monooxygenase [N-oxide-forming] 3.
Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds (PubMed:9224773).
Human | |
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Gene Name: | FMO3 |
Uniprot: | P31513 |
Entrez: | 2328 |
Belongs to: |
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FMO family |
dimethylaniline monooxygenase [N-oxide-forming] 3; Dimethylaniline oxidase 3; dJ127D3.1; EC 1.14.13.8; flavin containing monooxygenase 3; FMO 3; FMO form 2; FMO II; FMOII; Hepatic flavin-containing monooxygenase 3; hepatic flavin-containing monooxygenase-3; MGC34400; TMAU
Mass (kDA):
60.033 kDA
Human | |
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Location: | 1q24.3 |
Sequence: | 1; NC_000001.11 (171090873..171117819) |
Liver.
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
PMID: 1542660 by Lomri N., et al. Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver.
PMID: 8654418 by Dolphin C.T., et al. Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the flavin- containing monooxygenase family of man, FMO1, FMO3 and FM04.