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- Table of Contents
Facts about Dimethylaniline monooxygenase [N-oxide-forming] 2.
Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive.
Human | |
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Gene Name: | FMO2 |
Uniprot: | Q99518 |
Entrez: | 2327 |
Belongs to: |
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FMO family |
dimethylaniline monooxygenase [N-oxide-forming] 2; Dimethylaniline oxidase 2; EC 1.14.13.8; flavin containing monooxygenase 2 (non-functional); flavin containing monooxygenase 2; FLJ40826; FMO 1B1; FMO 2; FMO, pulmonary; FMO1B1; Pulmonary flavin-containing monooxygenase 2
Mass (kDA):
60.907 kDA
Human | |
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Location: | 1q24.3 |
Sequence: | 1; NC_000001.11 (171185208..171212686) |
Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain.
Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
PMID: 9804831 by Dolphin C.T., et al. The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein.
PMID: 11042094 by Whetstine J.R., et al. Ethnic differences in human flavin-containing monooxygenase 2 (FMO2) polymorphisms: detection of expressed protein in African-Americans.