FMO2 Antibodies

Dimethylaniline monooxygenase [N-oxide-forming] 2 (FMO2)

Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine.

Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive.

Gene Information

Human
Gene Name:	FMO2
Uniprot:	Q99518
Entrez:	2327

Family

Belongs to:
FMO family

Alternative Names

dimethylaniline monooxygenase [N-oxide-forming] 2; Dimethylaniline oxidase 2; EC 1.14.13.8; flavin containing monooxygenase 2 (non-functional); flavin containing monooxygenase 2; FLJ40826; FMO 1B1; FMO 2; FMO, pulmonary; FMO1B1; Pulmonary flavin-containing monooxygenase 2

Molecular Weight

Mass (kDA):
60.907 kDA

Genomic Context

Human
Location:	1q24.3
Sequence:	1; NC_000001.11 (171185208..171212686)

Tissue Specificity

Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain.

Subcellular Localizations

Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.

Diseases

• Trimethylaminuria
• Carcinoma
• Malignant Neoplasms
• Neoplasms
• Intolerant Of Heat
• Tuberculosis
• Inborn Errors Of Metabolism
• Malignant Neoplasm Of Breast
• Liver Damage
• Cytosine To Thymidine Transition Abnormality
• Neoplasm Invasiveness
• Macular Corneal Dystrophy Type I

• Hypokinesia
• Nonalcoholic Steatohepatitis
• Invasive Ductal Breast Carcinoma
• Mouth Neoplasms
• Feline Urological Syndrome
• Nervousness
• Invasive Lobular Breast Carcinoma

Pathways

• Localization
• Nadph Oxidation
• Pathogenesis
• Transport
• Methylation
• Reverse Transcription
• Response To Ionizing Radiation
• Dna Amplification
• Parturition

• Response To Ph
• Metaphase
• Oncogenesis

PTMs

• Oxidation

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FMO2

Boster Bio: Best Uses of the FMO2 Marker

This article provides a comprehensive overview of the Dimethylaniline monooxygenase (FMO2) marker as well as its genetic polymorphism and multichannel pipettes. Boster offers credits for products that allow you to share your results. You can also download the Boster Bio Best Uses of the FMO2 marker user guide for more information. After you have read the manual, you'll know what you need to do using the results of your research.

Dimethylaniline monooxygenase

This enzyme is involved in the oxidative metabolism process of many xenobiotics such as pesticides, drugs, tertiary and secondary amines. Its sequence is known as the canonicali series and is available as downloadable versions of this article. This information is offered to research purposes only and is not intended to replace medical advice given by a professional.

Its genetic polymorphism

Genetic polymorphism is the result of the evolution and alteration of DNA sequences. It is a hereditary characteristic that has been modified by natural selection. A polymorphism is as simple as any other characteristic of a species. It is a variation of one or more bases of the DNA sequence. Polymorphism is most commonly an alteration in one base pair. However, it could also occur over extended stretches of DNA referred to as SNPs.

Its potential therapeutic implications

One instance of a possible disease that vaccine development may aid is the covid-19 virus. While vaccination campaigns may help in preventing the spread of an epidemic but they increase the likelihood of resurgence due to the introduction of a new variant, national holidays, or diminishing populations. Additionally, less people are able to gain protection from the virus or vaccine due to the possibility of resurgence. In the end, vaccines are no longer considered an effective cure.

Its multichannel pipettes

Multichannel pipettes let you transfer reagents or samples into as many as eight wells at once. With precision and efficiency in mind, these devices are the ideal solution for enzyme reactions. They are also available in a 384-well model, making a synchronized setup simple. With sleek design and modern construction these multichannel pipettes are able to increase the speed and productivity of your lab.

The Novus is a popular choice among scientists due to its ergonomic design and flexibility. The pipettes are equipped with 10 distinct pipetting features, and are compatible with many types of uTIPs. These pipettes are a great option for many different purposes. They can be employed to collect a variety of samples, ranging from preparation of assays to sample analysis. They are extremely precise and easy to use.