Filamin-B Antibodies

AND FLNB ELISA kits, Filamin-B Proteins

Many biological assays use antibodies to detect Filamin-B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Filamin-B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Filamin-B antibodies...

We validate the specificity of these antibodies to Filamin-B by testing them on tissues known to express FLNB positively and negatively. Browse below to find the FLNB antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FLNB Infographic by Boster Bio

All FLNB Products

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Specificity

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Anti-Filamin-B FLNB Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A02562
100ul

Anti-FLNB Antibody (N-Term)

Human, Mouse

$299
Cat # M02562
50 µl

Anti-Filamin B/FLNB Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A02562-1
100 μg/vial

Anti-Filamin B/FLNB Antibody Picoband® (monoclonal, 11E2D2)

Human

IF, IHC, ICC, WB

$370
Cat # M02562-1
100 μg/vial

FLNB Overview

Facts about Filamin-B.

FLNB 3D structure. Source: alphafold

Filamin-B (FLNB)

Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins.

Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate.

Gene Information

Human
Gene Name:	FLNB
Uniprot:	O75369
Entrez:	2317

Family

Belongs to:

filamin family

Alternative Names

ABP-278filamin B, beta (actin binding protein 278); ABP-280 homolog; actin binding protein 278; Actin-binding-like protein; AOI; beta-filamin; DKFZp686O033; FH1; filamin B, beta; Filamin homolog 1; filamin-3; filamin-B; FLN1L; FLN3; FLN-B; Larsen syndrome 1 (autosomal dominant); LRS1; SCT; TABPABP-280; TAPDKFZp686A1668; Thyroid autoantigen; Truncated ABP; Truncated actin-binding protein

Molecular Weight

Mass (kDA):
278.164 kDA

Genomic Context


Human

Location:	3p14.3
Sequence:	3; NC_000003.12 (58008422..58172251)

Tissue Specificity

Ubiquitous. Isoform 1 and isoform 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells (HUVEC), retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord, platelet and Daudi cells. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer disease (AD). Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart.

Subcellular Localizations

[Isoform 1]: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, myofibril, sarcomere, Z line. In differentiating myotubes, isoform 1, isoform 2 and isoform 3 are localized diffusely throughout the cytoplasm with regions of enrichment at the longitudinal actin stress fiber. In differentiated tubes, isoform 1 is also detected within the Z-lines.; [Isoform 2]: Cytoplasm, cytoskeleton, stress fiber.; [Isoform 3]: Cytoplasm, cytoskeleton, stress fiber.; [Isoform 6]: Cytoplasm, cytoskeleton. Polarized at the periphery of myotubes.