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Filamin-C Antibodies
AND FLNC ELISA kits, Filamin-C Proteins
Many biological assays use antibodies to detect Filamin-C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Filamin-C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Filamin-C antibodies...
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FLNC Overview
Facts about Filamin-C.
Filamin-C (FLNC)
Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions in the Z lines in muscle cells.
Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. .
Gene Information
| Human | |
|---|---|
| Gene Name: | FLNC |
| Uniprot: | Q14315 |
| Entrez: | 2318 |
Family
| Belongs to: |
|---|
| filamin family |
Alternative Names
ABP-280; ABP280A; ABP-280-like protein; ABPA; ABP-L; ABPLABP-L, gamma filamin; Actin-binding-like protein; filamin 2; filamin C, gamma (actin binding protein 280); filamin C, gamma; filamin-2; filamin-C; FLJ10186; FLN2actin binding protein 280; FLNc; FLN-C; Gamma-filamin
Molecular Weight
Mass (kDA):
291.022 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q32.1 |
| Sequence: | 7; NC_000007.14 (128830406..128859274) |
Tissue Specificity
Highly expressed in striated muscles. Weakly expressed in thyroid, fetal brain, fetal lung, retina, spinal cord and bone marrow. Not expressed in testis, pancreas, adrenal gland, placenta, liver and kidney.
Subcellular Localizations
Cytoplasm. Membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme. Targeting to developing and mature Z lines is mediated by the intradomain insert.
Diseases
- Myopathy
- Muscular Dystrophy
- Weakness
- Malignant Neoplasms
- Muscle Weakness
- Distal Muscular Dystrophies
- Dystrophy
- Cardiomyopathies
- Neoplasms
- Haploinsufficiency
- Muscular Dystrophies, Limb-girdle
- Neuromuscular Diseases
Interacting Proteins
- ABL1
- CRK
- DYSF
- GRB2
- MYOT
- Trim54
- XIRP1
Pathways
- Methylation
- Dna Methylation
- Localization
- Pathogenesis
- Proteolysis
- Muscle Contraction
- Regulation Of Gene Expression
- Ossification
- Rna Splicing
- Demethylation
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FLNC
bosterbio.com/bosterbio-gene-info-cards/FLNC
References
PMID: 9791010 by Xie Z.-W., et al. Molecular cloning of human ABPL, an actin-binding protein homologue.
PMID: 11153914 by Chakarova C., et al. Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.