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- Table of Contents
Facts about Filamin-A.
Tethers cell surface- localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.
Human | |
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Gene Name: | FLNA |
Uniprot: | P21333 |
Entrez: | 2316 |
Belongs to: |
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filamin family |
ABP-280DKFZp434P031; ABPX; actin binding protein 280; Actin-binding protein 280; alpha-filamin; CVD1; EC 2.1.1.43; EC 6.3.4.4; Endothelial actin-binding protein; filamin A, alpha (actin binding protein 280); filamin A, alpha; filamin-1; filamin-A; FLN; FLN1OPD; FLN-A; FMD; MNS; NHBP; Non-muscle filamin; OPD1; OPD2; XLVD; XMVD
Mass (kDA):
280.739 kDA
Human | |
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Location: | Xq28 |
Sequence: | X; NC_000023.11 (154348531..154374638, complement) |
Ubiquitous.
Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Perikaryon. Cell projection, growth cone. Colocalizes with CPMR1 in the central region of DRG neuron growth cone (By similarity). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (By similarity).
PMID: 2391361 by Gorlin J.B., et al. Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring.
PMID: 8088819 by Patrosso M.C., et al. The exon-intron organization of the human X-linked gene (FLN1) encoding actin-binding protein 280.
*More publications can be found for each product on its corresponding product page