Filaggrin Antibodies

Filaggrin (FLG)

Aggregates keratin intermediate filaments and promotes disulfide-bond formation one of the intermediate filaments during terminal differentiation of mammalian epidermis. .

Gene Information

Human
Gene Name:	FLG
Uniprot:	P20930
Entrez:	2312

Family

Belongs to:
S100-fused protein family

Alternative Names

ATOD2; epidermal filaggrin; filaggrin; Profilaggrin

Molecular Weight

Mass (kDA):
435.17 kDA

Genomic Context

Human
Location:	1q21.3
Sequence:	1; NC_000001.11 (152302165..152325239, complement)

Tissue Specificity

Expressed in skin, thymus, stomach, tonsils, testis, placenta, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, or adrenal gland (PubMed:19384417). In the skin, mainly expressed in stratum granulosum of the epidermis (PubMed:1429717) (PubMed:19384417).

Subcellular Localizations

Cytoplasmic granule. In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719).

Diseases

• Dermatitis, Atopic
• Dermatitis
• Ichthyoses
• Ichthyosis Vulgaris
• Eczema
• Dermatologic Disorders
• Asthma
• Neoplasms
• Malignant Neoplasms
• Allergy
• Carcinoma
• Inflammation

• Tissue Adhesions
• Tumor Angiogenesis
• Psoriasis
• Rhinorrhea
• Leukemia
• Allergic Rhinitis (disorder)
• Mammary Neoplasms

Interacting Proteins

• KLK5

Pathways

• Pathogenesis
• Sensitization
• Localization
• Cell Proliferation
• Angiogenesis
• Bone Resorption
• Cell Growth
• Regeneration
• Cell Death
• Transport
• Immune Response
• Keratinocyte Differentiation
• Bone Remodeling

• Secretion
• Cell Differentiation
• Osteoclast Differentiation
• Reverse Transcription
• Translation
• Cell Adhesion
• Hypersensitivity

PTMs

• Phosphorylation
• Cleavage
• Acetylation
• Citrullination

• Methylation
• Dephosphorylation
• Glycosylation
• Prenylation

Research Areas

• Cell Biology
• Cellular Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FLG

Best Uses Of The FLG Marker From Boster Bio

This article will cover the use FLG Markers and high affinity primary antibodies from Boster Bio. We'll also go over some tips and tricks for optimizing your experiments. To learn more about FLG Markers, read on! Flow procedures are often complex. Boster Bio offers tips and optimization guides to help optimize flow procedures. Here are some important considerations when optimizing your experiment.

Boster Bio's high-affinity prima antibodies

Boster Bio has antibodies that can be used to test a variety proteins, cell types, diseases or other applications. Their antibody collection covers many areas, including neuroscience and immunology as well as biochemistry. Boster Bio products can be used for ELISA or WB and come with a Boster quality guarantee that each product will work as promised.

Boster Bio uses FLG-specific antibodies such as anti-Acquired Immunoglobulin and p62 monoclonal antibodies. The company also produces monoclonal antibodies that are specific for the BRCA1 and HTATIP genes.

FLG Marker

The FLG Marker is not only used for marking terrain but also serves as a tool for landscaping and utility projects. It can also be used to highlight buried hazards. Unlike other markers, FLG Markers are highly visible and help you identify buried water and gas lines. These flags are sold in bundles of 25 and are permanently attached to a staff. You will need to place them into one of your inventory slots in order to use them.

Optimization tips

Boster Bio provides extensive troubleshooting tips for IHC procedures in the BosterBio immunohistochemistry optimization book. Here are the most common problems researchers encounter when analyzing immunohistochemistry photos. This guide also contains optimization tips to improve the results of your IHC studies. This guide also includes a list of frequently-asked questions that addresses common IHC protocol issues such as high background or nonspecific staining.