Filaggrin Antibodies

AND FLG ELISA kits, Filaggrin Proteins

Many biological assays use antibodies to detect Filaggrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Filaggrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Filaggrin antibodies...

We validate the specificity of these antibodies to Filaggrin by testing them on tissues known to express FLG positively and negatively. Browse below to find the FLG antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FLG Infographic by Boster Bio

All FLG Products

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Specificity

Applications

Price

Anti-Filaggrin/FLG Antibody Picoband®

17 Q&As

Human

IHC, WB

$370
Cat # PB9870
100 μg/vial

Anti-Filaggrin (Keratinocyte Differentiation Marker) FLG Monoclonal Antibody

3 Q&As

Human

IHC

$486
Cat # M01063
100ug/vial

FLG Overview

Facts about Filaggrin.

Filaggrin (FLG)

Aggregates keratin intermediate filaments and promotes disulfide-bond formation one of the intermediate filaments during terminal differentiation of mammalian epidermis. .

Gene Information

Human
Gene Name:	FLG
Uniprot:	P20930
Entrez:	2312

Family

Belongs to:

S100-fused protein family

Alternative Names

ATOD2; epidermal filaggrin; filaggrin; Profilaggrin

Molecular Weight

Mass (kDA):
435.17 kDA

Genomic Context


Human

Location:	1q21.3
Sequence:	1; NC_000001.11 (152302165..152325239, complement)

Tissue Specificity

Expressed in skin, thymus, stomach, tonsils, testis, placenta, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, or adrenal gland (PubMed:19384417). In the skin, mainly expressed in stratum granulosum of the epidermis (PubMed:1429717) (PubMed:19384417).

Subcellular Localizations

Cytoplasmic granule. In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719).

Diseases

Dermatitis, Atopic
Dermatitis
Ichthyoses
Ichthyosis Vulgaris
Eczema
Dermatologic Disorders
Asthma
Neoplasms
Malignant Neoplasms
Allergy
Carcinoma
Inflammation

Tissue Adhesions
Tumor Angiogenesis
Psoriasis
Rhinorrhea
Leukemia
Allergic Rhinitis (disorder)
Mammary Neoplasms

Interacting Proteins

KLK5

Pathways

Pathogenesis
Sensitization
Localization
Cell Proliferation
Angiogenesis
Bone Resorption
Cell Growth
Regeneration
Cell Death
Transport
Immune Response
Keratinocyte Differentiation
Bone Remodeling

Secretion
Cell Differentiation
Osteoclast Differentiation
Reverse Transcription
Translation
Cell Adhesion
Hypersensitivity

PTMs

Phosphorylation
Cleavage
Acetylation
Citrullination

Methylation
Dephosphorylation
Glycosylation
Prenylation

Research Areas

Cell Biology
Cellular Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FLG

References

PMID: 1429717 by Presland R.B., et al. Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S-100-like calcium binding domain at the amino terminus.

PMID: 2740331 by McKinley-Grant L.J., et al. Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21.