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- Table of Contents
Facts about Fidgetin.
Microtubule severing may encourage rapid reorganization of cellular microtubule arrays as well as the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward movement of chromosome.
Human | |
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Gene Name: | FIGN |
Uniprot: | Q5HY92 |
Entrez: | 55137 |
Belongs to: |
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AAA ATPase family |
Fidgetin
Mass (kDA):
82.146 kDA
Human | |
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Location: | 2q24.3 |
Sequence: | 2; NC_000002.12 (163602611..163736155, complement) |
Nucleus matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.
PMID: 22672901 by Mukherjee S., et al. Human Fidgetin is a microtubule severing the enzyme and minus-end depolymerase that regulates mitosis.