Fidgetin (FIGN)

ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their endings, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes.

Microtubule severing may encourage rapid reorganization of cellular microtubule arrays as well as the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward movement of chromosome.